Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-11-03
2000-08-29
Fredman, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 5, 435 71, 435 911, 435 912, 530300, 530350, 5303871, 5303881, 536 231, 536 243, 536 2431, 536 2432, 536 2433, C12O 168, C12P 1934, C07H 2102, C07H 2104
Patent
active
061106763
ABSTRACT:
This invention relates to methods, kits and compositions suitable for the improved detection, analysis and quantitation of nucleic acid target sequences using probe based hybridization assays. The invention is more specifically directed to methods, kits and compositions suitable for suppressing the binding of detectable nucleic acid probes or detectable PNA probes to non-target nucleic acid sequences in an assay for a target nucleic acid sequence to thereby improve the reliability, sensitivity and specificity of the assay. The methods, kits and compositions of this invention are particularly well suited to the detection and analysis of nucleic acid point mutations.
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Coull James M.
Fiandaca Mark J.
Godtfredsen Sven E.
Hyldig-Nielsen Jens J.
Stefano Kyriaki
Boston Probes, Inc.
Dako A/S
Fredman Jeffrey
Gildea Brian D.
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