Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Reexamination Certificate
2009-08-18
2010-11-09
Witherspoon, Sikarl A (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
C568S316000, C568S322000
Reexamination Certificate
active
07829745
ABSTRACT:
Described herein are methods for synthesizing 1-aryl-2-tetralones in an efficient and highly selective manner. The reaction involves a one-step procedure for coupling an aryl halide to a 2-tetralone, where coupling occurs substantially at the 1-position of the 2-tetralone.
REFERENCES:
patent: 6506538 (2003-01-01), Breyne et al.
patent: 6969505 (2005-11-01), Tonkovich et al.
patent: 2005/0075325 (2005-04-01), Burnett et al.
patent: 0195592 (1986-09-01), None
patent: 1534421 (2006-09-01), None
Hamann et al. Palladium-Catalyzed Direct alpha-arylation of Ketones. Journal of the American Chemical Society, 19974, vol. 119, p. 12382-12383.
Kawatsura et al. Simple, Highly Active Palladium Catalysts for Ketone and Malonate Arylation. Joural of the American Chemical Society, 1999,vol. 121, p. 1473-1478.
Hamann et al. Palladium-Catalyzed Direct Alpha-Arylation of Ketones. Journal of the American Chemical Society, 1997, vol. 119, p. 12382-12383.
Nathaniel J. Alcock et al.; “Dynamic Kinetic Resolution-Asymmetric Transfer Hydrogenation of 1-Aryl-substituted Cyclic Ketones”; Tetrahedron Asymmetry, vol. 13, Issue 22, 2002, pp. 2485-2490.
Bruce L. Jensen et al., “A Concise Synthesis of 1-Substituted-2-Tetralones by Selective Diol Dehydration Leading to Ketone Transposition”; Tetrahedron Letters, 41, 2000 pp. 6029-6033.
B. Serge Kirkiacharian et al.; “Hydroborations: A New Route for the Preparation of 1-Alkul-(or Aryl) 2-Tetralones”; Synthetic Communication: An International Journal for Rapid Communication of Synthetic Organic Chemistry, 1532-2432, vol. 23, Issue 6, 1993, pp. 737-742.
Joseph M. Fox et al.; “Highly Active and Selective Catalysts for the Formation of α-Aryl Ketones”; J. Am. Chem. Soc., 2000, 122, 1360-1370.
Gabriela A. Grasa et al.; “A Highly Practical and General Route for α-Arylations of Ketones Using BIS-Phosphinoferrocene-Based Palladium Catalysts”, Organic Process Research & Development, 2008, 12, 522-529.
Corning Incorporated
Santandrea Robert P.
Witherspoon Sikarl A
LandOfFree
Methods for selectively synthesizing 1-aryl-2-tetralones does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for selectively synthesizing 1-aryl-2-tetralones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for selectively synthesizing 1-aryl-2-tetralones will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4246580