Methods for selectively stimulating proliferation of T cells

Details Methods for selectively stimulating proliferation of T cells Methods for selectively stimulating proliferation of T cells

2006-12-05

2006-12-05

Gambel, Phillip (Department: 1644)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

C424S093100, C424S093700, C424S534000, C424S577000, C424S578000, C435S002000, C435S375000, C435S377000

Reexamination Certificate

active

07144575

ABSTRACT:
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

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