Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Reexamination Certificate
2005-06-14
2005-06-14
Gamble, Phillip (Department: 1644)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
C424S130100, C424S141100, C424S143100, C424S144100, C424S153100, C424S154100, C424S173100, C424S093700, C424S534000, C424S577000, C424S578000, C435S002000, C435S007100, C435S007210, C435S007240, C435S375000, C435S377000, C530S387100, C530S388100, C530S388200, C530S388220, C530S388700, C530S388730, C530S388750
Reexamination Certificate
active
06905681
ABSTRACT:
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
REFERENCES:
patent: 5081029 (1992-01-01), Zarling et al.
patent: 5500348 (1996-03-01), Nishimura et al.
patent: 5858358 (1999-01-01), June et al.
patent: 5872222 (1999-02-01), Chang
patent: 6010902 (2000-01-01), Ledbetter et al.
patent: 6129916 (2000-10-01), Chang
patent: 6352694 (2002-03-01), June et al.
patent: 6534055 (2003-03-01), June et al.
patent: 0 440 373 (1991-08-01), None
patent: WO 90/05541 (1990-05-01), None
patent: WO 92/00092 (1992-01-01), None
1. Levine et al. Science 272: 1939-1943 (1995).
2. Levine et al. J. Immunol 159: 5921-5930 (1997).
3. Hellstrom et al. PNAS 98:6783-6788 (2001).
4. Orchard et al. Hum Gene Ther. 13: 979-988 (2002).
5. Pene et al. J. Immunol. Methods 283: 59-66 (2003).
Åsjö et al., “A Novel Mode of Human Immunodeficiency Virus Type 1 (HIV-1) Activation: Ligation of CD28 Alone Induces HIV-1 Replication on Naturally Infected Lymphocytes”J. of Virologyvol. 67, No. 7, pp. 4395-4398, Jul. 1993.
Azuma et al., “Functional Expression of B7/BB1 on Activated T Lymphocytes”J. of Exp. Med.vol. 177, pp 845-850, Mar. 1993.
Baroja et al., “The Anti-T Cell Monoclonal Antibody 9.3 (Anti-CD28) Provides a Helper Signal and Bypasses the Need for Accessory Cells in T Cell Activation with Immobilized Anti-CD3 and Mitogens”Cellular Immunologyvol. 120, pp. 205-217, 1989.
Baroja et al., “Cooperation Between an Anti-T Cell (Anti-CD28) Monoclonal Antibody and Monocyte-produced IL-6 in the Induction of T Cell Responsiveness to IL-2”The Journal of Immunologyvol. 141, No. 5, pp. 1502-1507, Sep. 1, 1988.
Damle and Doyle, “Stimulation Via the CD3 and CD28 Molecules Induces Responsiveness to IL-4 in CD4+CD29+CD45R−Memory T Lymphocytes”The Journal of Immunologyvol. 143, No. 6, pp. 1761-1767, Sep. 15, 1989.
Damle et al., “Differential Regulatory Signals Delivered by Antibody binding to the CD28 (Tp44) Molecule During the Activation of Human T Lymphocytes”The Journal of Immunologyvol. 140, No. 6, pp. 1753-1761, Mar. 15, 1988.
Diegel et al., “Regulation of HIV Production by Blood Mononuclear Cells from HIV-Infected Donors: II. HIV-1 Production Depends on T Cell-Monocyte Interaction,”AIDS Research and Human Retroviruses, vol. 9, No. 5, pp. 465-473, 1993.
Freedman et al., “Selective Induction of B7/BB-1 on Interferon-γ Stimulated Monocytes: A Potential Mechanism for Amplification of T Cell Activation through the CD28 Pathway”Cellular Immunologyvol. 137, pp. 429-437, 1991.
Galvin et al., “Murine B7 Antigen Provides A Sufficient Costimulatory Signal For Antigen-Specific and MHC-Restricted T Cell Activation”J. of Immunol.vol. 149, No. 12, pp. 3802-3808, Dec. 15, 1992.
Geppert, and Lipsky, “Accessory Cell Independent Proliferation of Human T4 Cells Stimulated by Immobilized Monoclonal Antibodies to CD3,”The Journal of Immunology, vol. 138, No. 6, pp. 1660-1666, Mar. 15, 1987.
Groux et al., “Activation-induced Death by Apoptosis in CD4+T Cells from Human Immunodeficiency Virus-infected Asymptomatic Individuals,”J. Exp. Med., vol. 175, pp. 331-340, Feb. 1992.
Hansen et al., “Monoclonal Antibodies Identifying a Novel T-Cell Antigen and Ia Antigens of Human Lymphocytes”Immunogeneticsvol. 10, pp. 247-260, 1980.
Hara et al., “Human T cell activation”J. Exp. Med.vol. 161, pp. 1513-1524, Jun. 1985.
Harding et al., “CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones”Naturevol. 356, pp 607-609, Apr. 1992.
Jong et al., “Regulation of T-Cell Differentiation by CD2 and CD28 Accessory Molecules”Immunologyvol. 74, pp. 175-182, 1991.
June et al., “Evidence for the Involvement of Three Distinct Signals in the Induction of IL-2 Gene Expression in Human T Lymphocytes”The Journal of Immunologyvol. 143, No. 1, pp. 153-161, Jul. 1, 1989.
June et al., “Role of the CD28 Receptor in T-Cell Activation”Immunology Todayvol. 11, No. 6, pp. 211-216, 1990.
June et al., “T-Cell Proliferation Involving the CD28 Pathway Is Associated with Cyclosporine-Resistant Interleukin 2 Gene Expression”Molecular and Cellular Biologyvol. 7, No. 12, pp. 4472-4481, Dec. 1987.
King et al., “CD28 Activation Promotes Th2 Subset Differentiation by Human CD4+Cells,”Eur. J. Immunol., vol. 25, pp. 587-595, 1995.
Koulova et al., “Identification of the Anti-CD3-Unresponsive Subpopulation of CD4+, CD45RA+Peripheral T Lymphocytes”The Journal of Immunologyvol. 145, No. 7, pp. 2035-2043, Oct. 1, 1990.
Ledbetter et al., “Antibodies to Tp67 and Tp44 Augment and Sustain Proliferative Response of Activated T Cells”The Journal of Immunologyvol. 135, No. 4, pp. 2331-2336, Oct. 1985.
Ledbetter et al., “Antibody Binding to CD5 (Tp67) and Tp44 T Cell Surface Molecules: Effects on Cyclic Nucleotides, Cytoplasmic Free Calcium, and cAMP-Mediated Suppression”The Journal of Immunologyvol. 137, No. 10, pp. 3299-3305, Nov. 15, 1986.
Ledbetter et al., “CD28 Ligation in T-Cell Activation: Evidence for Two Signal Transduction Pathways”Bloodvol. 75, No. 7, pp. 1531-1539, Apr. 1, 1990.
Ledbetter et al., “Crosslinking of Surface Antigens Causes Ionized Calcium in T Lymphocytes”Proceedings of the National Academy of Sciences, vol. 84, pp. 1384-1388, Mar. 1987.
Ledbetter et al., “Role of CD2 cross-linking in cytoplasmic calcium responses and T cell activation”Eur. J. Immunol.vol. 18, pp. 1601-1608, 1988.
Lee et al., “The Cd28 Signal Transduction Pathway in T Cell Activation”Advances in Regulation of Cell Growth, vol. 2; Cell Activation: Genetic Approachesvol. 2, Chapter 7, pp. 141-160, 1991.
Lesslauer et al., T90/44 (9.3 antigen). “A cell surface molecule with a function in human T cell activation”Eur. J. Immounol.vol. 16, pp. 1289-1296, 1986.
Linsley et al., “Binding of the B Cell Activation Antigen B7 to CD28 Costimulates T Cell Proliferation and Interleukin 2 mRNA Accumulation”Journal of Experimental Medicinevol. 173, pp. 721-730, Mar. 1991.
Martin et al., “A 44 Kilodalton Cell Surface Homodimer Regulates Interleukin 2 Production by Activated Human T Lymphocytes”The Journal of Immunologyvol. 136, No. 9, pp. 3282-3287, May 1, 1986.
McArthur and Raulet, “CD28-induced Costimulation of T Helper Type 2 Cells Mediated by Induction of Responsiveness to Interleukin 4,”J. Exp. Med., vol. 178, pp. 1645-1653, Nov. 1993.
Moran et al., “Regulation of HIV Production by Blood Mononuclear Cells from HIV-Infected Donors: I. Lack of Correlation Between HIV-1 Production and T Cell Activation,”AIDS Research and Human Retroviruses, vol. 9, No. 5, pp. 455-464, 1993.
Norton et al., “The CD28 Ligand, B7, Enhances IL-2 Production by Providing a Costimulatory Signal to T Cells”The Journal of Immunologyvol. 149, No. 5, pp. 1556-1561, Sep. 1, 1992.
Perrin et al., “Administration of Anti-CD28-Specific Monoclonal Antibody 9.3: Preclinical Studies,”Blood Suppl., p. 439a, No. 1747, 1991.
Pierres et al., “CD3lowHuman Thymocyte Population can readily be Triggered Via the CD2 and/or CD28
Gray Gary S.
June Carl H.
Nabel Gary J.
Rennert Paul D.
Thompson Craig B.
Gamble Phillip
Genetics Institute Inc.
Regents of the University of Michigan
The United States of America as represented by the Secretary of
Wilmer Cutler Pickering Hale and Dorr LLP
LandOfFree
Methods for selectively stimulating proliferation of T cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for selectively stimulating proliferation of T cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for selectively stimulating proliferation of T cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3509129