Methods for selectively stimulating proliferation of T cells

Details Methods for selectively stimulating proliferation of T cells Methods for selectively stimulating proliferation of T cells

2005-05-03

2005-05-03

Gambel, Phillip (Department: 1644)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

C424S130100, C424S141100, C424S143100, C424S144100, C424S153100, C424S154100, C424S173100, C424S093700, C424S534000, C424S577000, C424S578000, C435S002000, C435S007100, C435S007210, C435S007240, C435S375000, C435S377000, C530S387100, C530S388100, C530S388200, C530S388220, C530S388700, C530S388730, C530S388750

Reexamination Certificate

active

06887466

ABSTRACT:
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

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