Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2006-06-13
2006-06-13
Kruse, David H (Department: 1638)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S018000
Reexamination Certificate
active
07060501
ABSTRACT:
The present invention provides novel methods for determining whether a cell has incorporated a polynucleotide comprising the use of organophosphate hydrolase activity as a marker which has both selectable and screenable properties.
REFERENCES:
patent: 6380465 (2002-04-01), Barrett
patent: WO 99/53037 (1999-10-01), None
patent: WO 01/96543 (2001-12-01), None
Phillips et al, Proc. Natl. Acad. Sci. USA 1990, 87:8155-8159.
Blume et al., “Alteration of β-tubulin inNicotiana plumbaginifoliaconfers resistance to amiprophos-methyl”, Theor. Appl. Genet. 97:464-472 (1998).
Howard John A.
Pinkerton T. Scott
Wild James R.
Applied Biotechnology Institute
Kruse David H
Sweeney Patricia A.
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