Methods for screening monoclonal antibodies for therapeutic use

Details Methods for screening monoclonal antibodies for therapeutic use Methods for screening monoclonal antibodies for therapeutic use

1989-05-16

1994-03-22

Parr, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, 436501, 436503, 436508, 436514, 436531, 436548, 536 231, 536 235, 935 33, 935 34, 935 43, C12Q 168, G01N 33566, C07H 2102, C12N 1500

Patent

active

052963489

ABSTRACT:
The present invention provides a method for selecting from among many monoclonal antibodies capable of binding to a surface antigen on a tumor cell, the antibody which also can internalize into the cell and exert an appropriate molecular effect on the level of gene regulation in the tumor cell. Such antibodies can most effectively be employed to damage the tumor cell.

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