Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-06-13
2006-06-13
Kemmerer, Elizabeth (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C435S069100, C435S252300, C435S320100, C436S501000, C536S063000
Reexamination Certificate
active
07060451
ABSTRACT:
Methods are provided that are useful in assaying compounds for cognitive enhancing properties, anxiolytic properties, hypnotic properties, or antidepressant properties. These methods involve determining the in vitro efficacy and EC50of the compounds at defined series of cloned GABAAsubtype receptors composed of specific variants of α, β, and γ subunits in order to develop and an activity profile for each compound. Optionally, the binding affinities of the compounds at GABAAreceptors are also determined. As an additional step the in vivo effects of the compounds may be tested in animal models.
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Albaugh Pamela
Cassella James
Crandall Marci
Gallager Dorothy
Rajachandran Lavanya
Brannock Michael
Kemmerer Elizabeth
McDonnell Boehnen & Hulbert & Berghoff LLP
Neurogen Corporation
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