Methods for screening for compounds that modulate pd-1...

Details Methods for screening for compounds that modulate pd-1... Methods for screening for compounds that modulate pd-1...

2006-09-12

2006-09-12

Gambel, Phillip (Department: 1644)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S007210

Reexamination Certificate

active

07105328

ABSTRACT:
Disclosed are screening assays for identifying compounds which modulate the activity of, or signaling via, B7-4, or PD-1, especially which modulate the binding of B7-4 or PD-1 to a target molecule Further disclosed are a vaccine and also other compositions which contain agents that modulate signaling via PD-1.

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Kurita-Ochiai et al., Journal of Immunology, 2003, vol. 171, pp. 3576-3584.
Latchman et al., Nature Immunology, Mar. 2001, vol. 2, pp. 261-268.
Adachi, T., et al. “CD72 negatively regulates signaling through the antigen receptor of B cells.”J Immunol. Feb. 1, 2000, 164(3):1223-9.
Freeman, G.J., et al. “Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.”J Exp Med. Oct. 2, 2000, 192(7):1027-34.
Liu, Y., et al. “Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical toin vivonuclear-factor-κB induction.”Biochem J. Jan. 15, 2002, 361:255-65.

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