Methods for screening for antimycotics

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 731, 4351723, 43525421, C12Q 168, C12N 116, C12N 119, C12N 1500

Patent

active

056416270

ABSTRACT:
This application relates to screening methods for identification of antimycotic agents active in mycotic cell translation, the agents identified thereby, and uses of these agents.

REFERENCES:
patent: 4792520 (1988-12-01), Stambrook et al.
Paluh et al., 1988, "The cross-pathway control gene of Neurospora crassa, cpc-1, encodes a protein similar to GCN4 of yeast and the DNA-binding domain of the oncogene v-jun-encoded protein," Proc. Natl. Acad. Sci. U.S.A. 85:3728-3732.
Alani et al., "A Method for Gene Disruption That Allows Repeated Use of URA3 Selection in the Construction of Multiply Disrupted Yeast Strains," Genetics 116:541-545 (1987).
Balzi and Goffeau, "Multiple or pleiotropic drug resistance in yeast," Biochem. Biophys. Acta 1073:241-252 (1991).
Belcourt and Farabough, "Ribosomal Frameshifting in a Yeast Retrotransposon TY: tRNAs Induce Slippage on a 7 Nucleotide Minimal Site," Cell 62:339-352 (1990).
Boeke et al., "A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast Saccharomyces cerevisiae: 5-fluoro-orotic acid resistance",: Mol. Gen. Genetics 197:345-346 (1984).
Brugge, "New Intracellular Targets for Therapeutic Drug Design," Science 260:918-919 (1993).
Cashel and Rudd, "The Stringent Response, Escherichia coli and Salmonella typhimurium, " Cellular and Molecular Biology, ed. F.C. Neidhardt (Washington D.C., American Society for Microbiology 1987) 2:1410-1438.
Chien et al., "The two-hybrid system: A method to identify and clone genes for proteins that interact with a protein of interest," Proc. Natl. Acad. Sci. USA 88:9578-9582 (1991).
Christianson et al., "Multifunctional yeast high-copy-number shuttle vectors," Gene 110:119-122 (1992).
Clare and Oliver, "The Regulation of RNA Synthesis in Yeast," Mol. Gen. Genet. 188:96-102 (1982).
Clark, "New Approaches for Antifungal Drugs," ed. P.B. Fernandes (Boston:Birkhauser 1992) pp. 1-19.
Colthurst et al., "Elongation factor 3 (EF-3) from Candida albicans show both structural and functional similarity to EF-3 from Saccharomyces cerevisiae," Molecular Microbiology 6:1025-1033 (1992).
Colthurst et al., "Candida albicans and three other Candida species contain an elongation factor structurally and functionally analogous to elongation factor 3,"FEMS Microbiology Letters 80:45-50 (1991).
Dancis et al., "Ferric reductase of Saccharomyces cervisiae: Molecular characterization, role in iron uptake, and transcriptional control", Proc. Natl. Acad. Sci. USA 89:3869-3873 (1992).
Dever et al., "Phosphorylation of Initiation Factor 2.alpha. by Protein Kinase GCN2 Mediates Gene-Specific Translational Control of GCN4 in Yeast," Cell 68:585-596 (1992).
Eberhart et al., "Species Differences in the Toxicity and Cytochrome P450 IIIA-Dependent Metabolism of Digitoxin," Mol. Pharmacol. 40:859-867 (1991).
Erickson and Johnston, "Direct Cloning of Yeast Genes from an Ordered Set of Lambda Clones in Saccharomyces cerevisiae by Recombination in vivo," Genetics 134:151-157 (1993).
Ezekial and Elkins, "The Stimulation of Ribonucleic Acid Synthesis by Ribosome Inhibitors in Amino Acid-Starved Escherichia coli", Biochem. Biophys. Acta 166:466-474 (1968).
The Federal Register 47 (no. 56): 12558-12564 (1982).
Fields and Song, "A novel genetic system to detect protein-protein interactions," Nature 340:245-246 (1989).
Firoozan et al., "Quantitation of Readthrough of Termination Codons in Yeast using a Novel Gene Fusion Assay," Yeast 7:173-183 (1991).
Graybill, "New Antifungal Agents," Eur. J. Clin. Microbiol. Infect. Dis. 8:402-412 (1989).
Gross and Pogo, "Control of Ribonucleic Acid Synthesis in Eukaryotes 3. The Effect of Cycloheximide and Edeine on RNA Synthesis in Yeast," Biochemistry 15:2082-2086 (1976).
Hershey, "Translation Control in Mammalian Cells," C.C. Richardson ed., Ann. Rev. of Biochem. (Annual Review, Inc. 1991) 60:717-755.
Higgins et al., "Turnover of mRNA in prokaryotes and lower eukaryotes," Curr. Opin. in Gen. and Dev. 2:739-747 (1992).
Hinnebusch and Liebman, "Protein Synthesis and Translational Control in Saccharomyces cerevisiae," The Molecular Biology of the Yeast Saccharomyces, eds. J.R. Broach, J.R. Pringle and E.W. Jones (New York: CSH Laboratory Press, 1991) pp. 627-735.
Hinnenbush et al., "A synthetic HIS4 regulatory element confers general amino acid control on the cytochrome c gene (2CYC1) of yeast," Proc. Natl. Acad. Sci. USA 82:498-502 (1985).
Huston and Logan, "Detoxification of the organophosphorus insecticide chlorfenvinphos by rat, rabbit and human liver enzymes," Xenobiotica 16:87-93 (1986).
Hwang et al., "Construction of a Promoter-Probe Vector with the PH05 Gene Encoding Repressible Acid Phosphatase in Saccharomyces cerevisiae," Appl. Microbiol. Biotechnol. 28:155-159 (1988).
Hwang et al., "The Identification of a Domain in Escherichia coli Elongation Factor Tu That Interacts with Elongation Factor Ts," J. Biol. Chem. 267:22198-22205 (1992).
Hwang et al., "Mutagenesis of Bacterial Elongation Factor Tu at Lysine 136," J. Biol. Chem. 264:8304-8309 (1989).
Koltin, "Targets for Antifungal Drug Discovery," Annual Reports in Medicinal Chemistry, ed. James A. Bristol, Harcourt Brace Jovanovich, San Diego, Academic Press, Inc., 25:141-148 (1989).
Lanker et al., "Autoregulation of the Yeast Lysyl-tRNA Synthetase Gene Gcd5/KRS1 by Translational and Transcriptional Control Mechanisms," Cell 70:647-657 (1992).
Leeds et al., "Gene Products That Promote mRNA Turnover in Saccharomyces cerevisiae," Mol. Cell. Biol. 12:2615-2177 (1992).
Lindahl and Hinnebusch, "Diversity of mechanisms in the regulation of translation in prokaryotes and lower eukaryotes," Curr. Opin. in Gen. and Dev. 2:720-726 (1992).
Merrick, "Mechanism and Regulation of Eukaryotic Protein Synthesis," Microbiological Reviews 56:291-315 (1992).
Min and Zassenhaus, "Identification of Protein Complex That Binds to a Dodecamer Sequence Found at the 3' Ends of Yeast Mitochondrial mRNAs," Mol. Cell. Biol. 13:4167-4173 (1993).
Miranda et al., "Flavin-Containing Monooygenase: A Major Detoxifying Enzyme for the Pyrrolizidine Alkaloid Senecionine in guinea Pig Tissues," Biochem. Biophys. Res. Commun. 178:546-552 (1991).
Moehele and Hinnebusch, "Association of RAP1 Binding Sites With Stringent Control of Ribosomal Protein Gene Transcription in Saccharomyces cerevisiae," Mol. Cell. Biol. 11:2723-2735 (1991).
Nieuwint et al., "Mutational analysis of the upsream activation site of yeast ribosomal protein genes," Current Genetics 15:247-251 (1989).
Nelson et al., "The Translation Machinery and 70 kd Heat Shock Protein Cooperate in Protein Synthesis," Cell 71:97-105 (1992).
Oliver and McLaughlin, "The Regulation of RNA Synthesis in Yeast 1: Starvation Experiments," Mol. Gen. Genetics 154:145-153 (1977).
Paull et al., "The Synthesis of XTT: A New Tetrazolium Reagent that is Bioreducible to a Water-Soluble Formazan," J. Heterocyclic Chem. 25:911-914 (1988).
Pon and Schatz, "Biogenesis of Yeast Mitochondria," The Molecular Biology of the Yeast Saccharomyces, eds. J.R. Broach, J.R. Pringle, and E.W. Jones (New York: CSH Laboratory Press 1991) pp. 333-406.
Qin et al., "Sequence Analysis of the Translational Elongation Factor 3 From Saccharomyces cerevisiae," J. Biol. Chem. 265:1903-1912 (1990).
Rameriz et al., "Mutations Activating the Yeast elF2.alpha. Kinase GCN2: Isolation of Alleles Altering the Domain Related to Histidyl-tRNA Synthetases," Mol. Cell. Biol. 12:5801-5815 (1992).
Ray and Butow, "Regulation of Mitochondrial Ribosomal RNA Synthesis in Yeast," Mol. Gen. Genet. 173:227-238 (1979).
Sandbaken et al., "Protein Synthesis in Yeast. Structural and functional analysis of the gene encoding elongation factor 3," J. Biol. Chem. 200:15838-15844 (1990).
Sandbaken et al., "Isolation and characterization of the structural gene encoding elongation factor 3," Biochem. Biophys. Acta 1050:230-234 (1990).
Siegel, "Effect of Fungicides on Protein Synthesis," Antifungal Compounds, sr. ed. Hugh D. Sisler (New York, Marcel Dekker, Inc. 1977) vol. 2:399-438.
Sikorski and Hieter, "A System of Shuttle Vectors and Yeast Host Strains Designed for Efficient

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for screening for antimycotics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for screening for antimycotics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for screening for antimycotics will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-148395

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.