Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-07
1997-11-11
Myers, Carla J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435 4, 435 911, 435 15, 935 77, 935 78, 514 44, 436 64, C12Q 168, C12P 1934
Patent
active
056862458
ABSTRACT:
Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
REFERENCES:
patent: 4737454 (1988-04-01), Dattagupta et al.
patent: 5489508 (1996-02-01), West et al.
Hiyama et al. International Journal of Oncology (1995) 6:13-16.
Nurnberg et al, Human Genetics (1993) 91: 190-192.
Shirotani et al, Lung Cancer (1994) 11:29-41.
Bacchetti et al, International Journal of Oncology, (1995) 7:423-432.
Odagiri et al. Cancer (1994) 73: 2978-2984.
Schmitt et al, Genes, Chromosomes and Cancer (1994) 11:171-177.
Butler et al, Cancer Genetics and Cytogenetics (1996) 86:50-53.
Harley, Mutation Research (1991) pp. 271-282, vol. 256.
Allsopp et al., "Telomere length predicts replicative capacity of human fibroblasts," proc. Natl. Acad. Sci. USA 89:10114-10118 (1992).
Greider and Blackburn, "A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis," Nature 337:331-337 (1989).
Cotten, "The in vivo application of ribozymes," Trends in Biotechnology 8:174-178 (1990).
Harley et al., "The Telomere Hypothesis of Cellular Aging," Experimental Gerontology 27:375-382 (1992).
Shay et al., "Loss of telomeric DNA during aging may predispose cells to cancer (Review)," Int'l J. Oncology 3:559-563 (1993).
Windle and McGuire, "Telomeres: the long and the short of it," Proceedings of the American Association for Cancer Research 33:594-595 (1992).
Counter et al., "Stabilization of Short Telomeres and Telomerase Activity Accompany Immortalization of Epstein-Barr Virus-Transformed Human B Lymphocytes," J. Virology 68:3410-3414 (1994).
Klingelhutz et al., "Restoration of Telomeres in Human Papoillomavirus-Immortalized Human Anogenital Epithelial Cells," Molecular and Cellular Biology 14:961-969 (1994).
Counter et al., "Telomerase activity in human ovarian carcinoma," Proc. Natl. Acad. Sci. USA 91:2900-2904 (1994).
Strahl and Blackburn, "The effects of nucleoside analogs on telomerasae and telomeres in Tetrahymena," Nucleic Acids Research 22:893-900 (1994).
Zahler et al., "Inhibition of Telomerase by G-quarter DNA Structures," pp. 718-720, Nature, vol. 350, (Apr. 25, 1991).
Eck and Nabel, "Antisense oligonucleotides for therapeutic intervention", Current Opin. in Biotech, 2:897 (1991).
Harley, "Telomere Loss: Mitotic Clock or Genetic Time Bomb?" 256 Nature 271 (1991).
Yu et al., "Developmentally Programmed Healing of Chromosomes by Telomerase in Tetrahymena," 67 Cell 823 (1991).
Harley eta l., "Telomeres Shorten During Ageing of Human Fibroblasts" 345 Nature 458 (1990).
Blackburn, "Structure and Function of Telomeres", 350 Nature 572 (1991).
Cech, "Ribozymes and their medical implications", 260 J. of Amer. Med. Assoc. 3030 (1988).
Harley, Mutation Research, 256:271-282 (1991).
Counter et al., "Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity," EMBO J 11:1921-1929 (May 5, 1992).
Greider et al., "Telomerase is Processive", Molecular and Cellular Biology, 11: 4572-4580 (1991).
Blackburn et al., "Recognition and Elongation of Telomeres by Telomerase" Genome, 312:553-560 (1989).
Greider and Blackburn, "The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity," Cell 51: 887-898 (1987).
S. Wang and V. Zakian, "Telomere-telemere recombination provides an express pathway for telomere acquisition", Nature 345:456 (1990).
Goldstein, "Replicative senescence: the human fibroblaste comes of age", Science 249:1129 (1990).
Smith et al., "Intraclonal variation in proliferative potential of human diploid fibroblases: stochastic mechanisms for cellular aging", Science 207:82 (1980).
Ohno, "Strict relationship between dialyzed serum concentration and cellular life span" Mechanisms of Aging and Development 11:179 (1979).
Hayflick et al., "The serial cultivation of human diploid cell strains", Experimental Cell Research 25:585 (1961).
Szostak, "The beginning of the ends", Nature 337:303 (1989).
Jankovic et al., "Telomere loss and cancer", Nature 350:197 (1991).
Gall, "Tying up loose ends", Nature 344:108 (1990).
Yu et al., "In vivo alteration of telomere sequences and senscence caused by mutated Tetrahymena telomerase RNAs", Nature 344:126 (1990).
Harrington and Greider, "Telomerase primer specificity and chromosome healing", Nature 353:451 (1991).
Gray et al., "Cloning and expression of genes for the Oxytricha telomere-binding protein specific subunit interactions in the telomeric complex", Cell 67:807.
Muller et al., "New telomere formation after developmentally regulated chromosomal breakage during the process of chromosome diminution in Ascaris lumbricoides" Cell 67:815 (1991).
Yu and Blackburn, "Developmentally programmed healing of chromosomes by teleomerase in Tetrahymena", cell 67:823 (1991).
Greider, "Telomeres, telomerase and senescence", Bioessays 12:363 (1990).
Hendersen et al., "Telomere G-strand structure and function analyzed by chemical protection, base analogue substitution, and utilization by telomerase in vitro", Biochemistry 29:732 (1990).
Gottschling et al., "Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription", Cell 63;751 (1990).
Lundblad and Szostak, "A mutant with a defect in telomere elongation leads to senescence in yeast", Cell 57:633 (1989).
Blackburn, "The molecular structure of centromeres and telomeres", Annual Reviews in Biochemistry 53:163 (1984).
Olovnikov, "A theory of marginotomy", J. Theoretical Biology 41:181 (1973).
Cooke and Smith, "Variability at the telomeres of the human X/Y pseudoautosomal region", CSHSQB LI:213 (1986).
Greider, "Chromosome first aid", Cell 67:645 (1991).
Morin, "The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes ITAGGG repeats", Cell 59:521 (1989).
Ham and McKeehan, "Media and growth requirements", Methods in Enzymology LVIII:44 (1979).
Starling et al., "Extensive telomere repeat arrays in mouse are hypervariable", Nucleic Acids Research 18:6881 (1990).
Wright et al EMBO Journal (1996) vol. 15 No. 7, pp. 1734-1741.
Shay Jerry
West Michael D.
Wright Woodring
Hellenkamp Amy S.
Kaster Kevin
Myers Carla J.
University of Texas System Board of Regents
Warburg Richard J.
LandOfFree
Methods for screening for agents which modulate telomere length does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for screening for agents which modulate telomere length, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for screening for agents which modulate telomere length will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1227820