Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1994-07-12
1996-09-24
Gitomer, Ralph J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435968, C12Q 102
Patent
active
055590047
ABSTRACT:
Intracellular free calcium concentrations are lowered by administering certain dihydropyridine derivatives to cells. Dihydropyridine and other test compounds are screened for their ability to lower intracellular free calcium, particularly by inhibiting the influx of calcium through calcium leak channels, and the identified compounds incorporated into pharmaceutical compositions. Exemplary dihydropyridine derivative compounds include 4-(3-trifluoromethylphenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyr idine; 4-(4-bromophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine; 4-(4-trifluoromethylphenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyr idine; 4-(4-methylphenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine; and 4-(4-cyanophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine.
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Fritz Lawrence C.
John Varghese
Steinhardt Richard A.
Athena Neurosciences, Inc.
Gitomer Ralph J.
The Regents of the University of California
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