Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-03-27
1998-03-03
Fitzgerald, David L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 72, 435 721, 435 723, 435 691, 4351723, 435 29, 436501, 536 241, G01N 3368, G01N 3374, C12Q 102, C12N 1500
Patent
active
057232911
ABSTRACT:
The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters having an AP1 site linked to a reporter gene. Compounds capable of inducing or blocking expression of the reporter gene can thus be identified. The compounds may be further tested for the ability to modulate the standard estrogen response, as well.
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Hunt C. Anthony
Kushner Peter
Lopez Gabriella
Webb Paul
Williard Renee
Fitzgerald David L.
Kemmerer Elizabeth C.
The Regents of the University of California
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