Methods for reversing multidrug resistance

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514211, 5142335, 5142352, 514253, 514255, 514472, A61K 31445, A61K 3155, A61K 31535, A61K 31495, A61K 3150, A61K 3134

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06121292&

ABSTRACT:
The present invention provides methods for reversing multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene. This invention also provides methods for treating neoplasms in a mammal which comprises administering to a mammal in need of this treatment a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene in combination with an oncolytic agent.

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Jones, et al., J. Med. Chem., 27:1057-1066 (1984).
M. Lehnert, J. Neuro-Oncology, 22:239-243 (1994).
Osborne, et al., J. Clinical Oncology, 7(6):710-717 (1989).

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