Methods for rendering amplified nucleic acid subsequently unampl

Details Methods for rendering amplified nucleic acid subsequently unampl Methods for rendering amplified nucleic acid subsequently unampl

1989-10-26

1993-06-22

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 91, 435808, 435 92, 436501, 436805, 514455, 935 17, 935 78, 935 88, 536 231, 536 221, C12Q 168

Patent

active

052216080

ABSTRACT:
Method for treating nucleic acid that is to be amplified such that the nucleic acid is, after amplification, subsequently unamplifiable. Nucleic acid amplification is performed in a reaction containing means in the presence of an isopsoralen. The reaction is thereafter irradiated to render the amplified nucleic acid substantially unamplifiable.

REFERENCES:
patent: 4312883 (1962-01-01), Baccichetti et al.
Piette et al. (1983) Proc. Nat'l Acad Sci (USA), vol. 80, pp. 5540-5544.
Brown et al. (1982) Gene, vol. 20, pp. 139-144.

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