Methods for regulation of stem cells

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S455000, C435S372000

Reexamination Certificate

active

07850960

ABSTRACT:
Methods are provided for increasing stem cells, hematopoietic progenitor/stem cells, mesenchymal progenitor/stem cells, mesodermal progenitor/stem cells, muscle progenitor/stem cells, or neural progenitor/stem cells in vivo in a mammalian subject. Methods are also provided for treating an immune related disease, a mesenchymal/mesoderm degenerative disease, or a neurodegenerative disease in a mammalian subject in need thereof.

REFERENCES:
patent: 5994084 (1999-11-01), Anderton et al.
patent: 6057117 (2000-05-01), Harrison et al.
patent: 6171781 (2001-01-01), Crabtree et al.
patent: 6479255 (2002-11-01), Rubin et al.
patent: 6608063 (2003-08-01), Nuss et al.
patent: 6784155 (2004-08-01), Wolpe et al.
patent: 2001/0053351 (2001-12-01), Hoeflich et al.
patent: 2002/0114772 (2002-08-01), Morgan et al.
patent: 2004/0014209 (2004-01-01), Lassar et al.
patent: 2004/0018531 (2004-01-01), Jamieson et al.
patent: 2004/0038860 (2004-02-01), Allen et al.
patent: 2004/0087016 (2004-05-01), Keating et al.
patent: 2004/0092535 (2004-05-01), Barsanti et al.
patent: 2004/0209878 (2004-10-01), Guzi et al.
patent: 2004/0224887 (2004-11-01), Jessel et al.
patent: 2006/0004043 (2006-01-01), Bhagwat et al.
patent: 2008/0207594 (2008-08-01), Mussmann et al.
patent: 2005/051942 (2005-06-01), None
patent: 2007016485 (2007-02-01), None
Sato et al. (Nature Medicine, Jan. 2004; 10(1): 55-63).
Dravid et al. (Stem Cells. 2005; 23(10): 1489-1501).
James et al. (Development. 2005. 132: 1273-1282).
Bendall et al. (Nature. 2007. 448(7157): 1015-1021).
Ring et al. (Diabetes. Mar. 2003; 52:588-595).
Moon et al. (Nature Reviews Genetics. Sep. 2004; 5: 689-699).
Sauvageau et al., “In vitro and in vivo expansion of hematopoietic stem cells,”Oncogene, 2004, 23, 7223-7232.
Ding et al., “A role for chemistry in stem cell biology,”Nature Biotechnology, 2004, 22(7), 833-840.
Alberdi, “Binding of Pigment Epithelium-derived Factor (PEDF) to Retinoblastoma Cells and Cerebellar Granule Neurons,”J. Biol. Chem., 1999, 274, 31605-31612.
Aymerich et al., “Evidence for Pigment Epithelium-Derived Factor Receptors in the Neural Retina,”Invest. Ophthalmol. Vis. Sci., 2001, 42(13), 3287-3293.
Barker et al., “Transplantation of 2 Partially HLA-matched Umbilical Cord Blood Units to Enhance Engraftment in Adults with Hematologic Malignancy,”Blood, 2005, 105(3), 1343-1347.
Baron et al., “Hematopoietic Cell Transplantation: Five Decades of Progress,”Arch. Med. Res., 2003, 34, 528-544.
Behrens et al., “Functional Interaction of an Axin Homolog, Conductin, with β- Catenin, APC, and GSK3β,”Science, 1998, 280, 596-599.
Berman et al., “Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade,”Science, 2002, 297, 1559-1561.
Bhardwaj et al., “Sonic Hedgehog Induces the Proliferation of Primitive Human Hematopoietic Cells via BMP Regulation,”Nat. Immunol., 2001, 2(2), 172-180.
Bhatia et al., “A Newly Discovered Class of Human Hematopoietic Cells with SCID-repopulating Activity,”Nat. Med., 1998, 4(9), 1038-1045.
Bhatia et al., “Purification of Primitive Human Hematopoietic Cells Capable of Repopulating Immune-deficient Mice,”Proc. Natl. Acad. Sci. USA, 1997, 94, 5320-5325.
Calvi et al., “Osteoblastic Cells Regulate the Haematopoietic Stem Cell Niche,”Nature, 2003, 425, 841-846.
Cheng et al., “Hematopoietic Stem Cell Quiescence Maintained by p21cipl/wafl,”Science2000, 287, 1804-1808.
Cline et al., “Effects of a Novel Glycogen Synthase Kinase-3 Inhibitor on Insulin-Stimulated Glucose Metabolism in Zucker Diabetic Fatty (fa/fa) Rats,”Diabetes, 2002, 51, 2903-2910.
Cohen et al., “GSK3 Inhibitors: Development and Therapeutic Potential,”Nat. Rev. Drug Dis., 2004, 3, 479-487.
Cohen, “The Hormonal Control of Glycogen Metabolism in Mammalian Muscle by Multivalent Phosphorylation,”Biochem. Soc. Trans., 1979, 7, 459-480.
Cohen et al., “Hematopoietic Stem-cell Transplantation Using Umbilical-cord Blood,”Leuk Lymphoma. 2003, 44(8), 1287-1299.
DasGupta et al., “Multiple Roles for Activated LEF/TCF Transcription Complexes during Hair Follicle Development and Differentiation,”Development, 1999, 126, 4557-4568.
Derksen et al., “Illegitimate WNT Signaling Promotes Proliferation of Multiple Myeloma Cells,”Proc. Natl Acad. Sci. USA, 2004, 101(16), 6122-6127.
Devine et al., “Clinical Application of Hematopoietic Progenitor Cell Expansion: Current Status and Future Prospects,”Bone Marrow Transplant, 2003, 31, 241-252.
Dyer et al., “Indian Hedgehog Activates Hematopoiesis and Vasculogenesis and Can Respecify Prospective Neurectodermal Cell Fate in the Mouse Embryo,”Development, 2001, 128, 1717-1730.
Emami et al., “A Small Molecule Inhibitor of β-catenin/CREB-binding Protein Transcription,”Proc. Natl Acad. Sci. USA, 2004, 101(34), 12682-12687.
Embi et al., “Glycogen Synthase Kinase-3 from Rabbit Skeletal Muscle,”Eur. J. Biochem., 1980, 107, 519-527.
Espinosa et al., “Phosphorylation by Glycogen Synthase Kinase-3β Down-regulates Notch Activity, a Link for Notch and Wnt Pathways,”J. Biol. Chem., 2003, 278(34), 32227-32235.
Foltz et al., “Glycogen Synthase Kinase-3β Modulates Notch Signaling and Stability,”Curr. Biol., 2002, 12, 1006-1011.
Frame et al., “GSK3 Takes Centre Stage More Than 20 Years after its Discovery,”Biochem J., 2001, 359, 1-16.
Frank-Kamenetsky et al., “Small-molecule Modulators of Hedgehog Signaling: Identification and Characterization of Smoothened Agonists and Antagonists,”J. Biology, 2002, 1(2), 10.1-10.19.
Giles et al., “Caught up in a Wnt Storm: Wnt Signaling in Cancer,”Biochim. Biophys. Acta, 2003, 1653, 1-24.
Giralt, “Bone Marrow Transplant in Myelodysplastic Syndromes: New Technologies, Same Questions,”Curr Hematol Rep., 2004, 3, 165-172.
Gluckman, “Current Status of Umbilical Cord Blood Hematopoietic Stem Cell Transplantation,”Exp. Hematol., 2000, 28, 1197-1205.
Goodrich et al., “Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants,”Science, 1997, 277, 1109-1113.
Gunther et al., “Impact of p53 Loss on Reversal and Recurrence of Conditional Wnt, induced Tumorigenesis,”Genes Dev., 2003, 17, 488-501.
He et al., “A Monoclonal Antibody against Wnt-1 Induces Apoptosis in Human Cancer Cells,”Neoplasia, 2004, 6(1), 7-14.
Issack et al., “Altered Expression of Helix-Loop-Helix Transcriptional Regulators and Cyclin D1 in Wnt-1-transformed PC12 Cells,”Cell Growth Differ., 1998, 9, 837-845.
Jarriault et al., “Signalling Downstream of Activated Mammalian Notch,”Nature, 1995, 377, 355-358.
Jay et al., “Identification of a Novel Population of Human Corn Blood Cells with Hematopoietic and Chondrocytic Potential,”Cell Research, 2004, 14(4), 268-282.
Jho et al., “Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway,”Mol. Cell Biol., 2002, 22(4), 1172-1183.
Jia et al., “Shaggy/GSK3 Antagonists Hedgehog Signalling by Regulating Cubitus Interruptus,”Nature, 2002, 416, 548-552.
Karanu et al., “Human Homologues of Delta-1 and Delta-4 Function as Mitogenic Regulators or Primitive Human Hematopoietic Cells,”Blood, 2001, 97(7), 1960-1967.
Karanu et al., “The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells,”J. Exp. Med., 2000, 192(9), 1365-1372.
Kim et al., “Proof-of-Principle: Oncogenic β-Catenin is a Valid Molecular Target for the Development of Pharmacological Inhibitors,”Mol. Cancer Ther., 2002, 1, 1355-1359.
King, “Roughing up Smoothened: Chemical Modulators of Hedgehog Signaling,”J. Biology, 2002, 1(2), 8.1-8.4.
Larochelle et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for regulation of stem cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for regulation of stem cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for regulation of stem cells will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4187138

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.