Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2003-08-20
2008-07-29
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
07405041
ABSTRACT:
Among the different intrastrand quadruplex structures that can arise from duplex DNA, it has been discovered that the nucleotide sequences (GGA)4(SEQ ID NO: 1) and (GGA)3GG (SEQ ID NO: 2) form biologically significant quadruplex structures. Thus, provided herein are methods for identifying molecules that modulate the biological activity of quadruplex DNA comprising the nucleotide sequence (GGA)4(SEQ ID NO: 1) or the nucleotide sequence (GGA)3GG (SEQ ID NO: 2), and specifically, methods for identifying molecules that bind such quadruplexes. Also provided herein are methods for modulating the biological activity of a biologically significant native quadruplex DNA with a molecule identified by the methods described herein.
REFERENCES:
patent: 5176996 (1993-01-01), Hogan et al.
patent: 6156763 (2000-12-01), Kerwin et al.
patent: 6544784 (2003-04-01), Bullerdiek et al.
patent: 2002/0115057 (2002-08-01), Young
patent: 2003/0207834 (2003-11-01), Dale et al.
patent: 2004/0005601 (2004-01-01), Siddiqui-Jain et al.
Izbicka et al. Telomere-interactive agents affect proliferation rates and induce chromosomal destabilization in sea urchin embryos. Anti-Cancer Drug Desgin. (1999) 14: 355-365.
Lee. The stability of polypurine tetraplexes in the presence of mono-and divalent cations. Nucleic Acids Research. (1990) 18(20): 6057-6060.
Williams et al. Advantages of firefly luciferase as a reporter gene: application to the interleukin-2 gene promoter, Analytical Biochemistry. (1989) 176: 28-32.
Benson et al. GenBank. Nucleic Acids Research (2000) 28(1): 15-18.
GenBank® GI: 927059, Apr. 9, 1996 [online], [retrieved on Jun. 4, 2007], retrieved from the Internet: <URL: www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=927059).
Anantha et al., Biochemistry 37(9):2709-2714 (1998).
Cohen et al., J Biol Chem 72:2901-2913 (1997).
Datta et al., JACS 123:9612-9619 (2001).
Ewulonu et al., Proc Natl Acad Sci 88:4675 (1991).
Han et al., Nucl. Acids Res. 27:537-542 (1999).
He et al., Science 281:1509-1512 (1998).
Hurley et al., Pharmacology & Therapeutics 85:141-158 (2000).
Hurley, Nature Rev. Cancer 2:188-200 (2002).
Jin & Pike, Mol. Endocrinol. 10:196-205 (1996).
Marathias and Bolton, Biochemistry 38:4355-4364 (1999).
Matsugami et al., J. Mol. Biol. 313:255-269 (2001).
Matsugami et al., J. Biol. Chem. 278(30):28147-28153 (2003).
Postel et al., Mol. Cell. Biol. 9:5123-5133 (1989).
Postel, J. Biol. Chem. 274:22821-22829 (1999).
Ren et al., Biochemistry 38:16067-16075 (1999).
Rustighi et al., Biochem. Biophys. Res. Comm. 265:439-447 (1999).
Rustighi et al., Biochemistry 41:1229-1240 (2002).
Shin-ya et al., J. Am. Chem. Soc. 123:1262 (2001).
Simonsson et al., Nucleic Acids Research 26(5):1167-1172 (1998).
Tone et al., J Immunology 165:286-91 (2000).
Weitzmann et al., J. Biol. Chem. 271:20958-20964 (1996).
Invitation to Pay Additional Fees for PCT/US03/26267 mailed on Sep. 16, 2004, 2 pages.
Gowan et al., Molecular Pharmacology (2002) 61:1154-1162.
International Search Report for PCT/US03/26267, mailed on Dec. 8, 2004, 5 pages.
Mergny et al., Anti-Cancer Drug Design (1999) 14:327-339.
Armitage Group, the, “Hybridization of Peptide Nucleic Acid Probes to Structured DNA and RNA Targets” at <http://www.chem.cme.edu/groups/army/research/probes.html> (Visited May 15, 2003).
Arthanari et al., Chemistry and Biology (2001) 8:221-230.
Arthanari et al., Anti-Cancer Drug Design (1999) 14:317-326.
Cooney et al., Science (1988) 241:456-459.
Doyle et al., “Inhibition of Gene Expression Inside Cells by Peptide Nucleic Acids: Effect of mRNA Target Sequence, Mismatched Bases, and PNA Length” Biochemistry 40:53-64 (2001).
Finkenzeller et al., “Sp1 Recognition Sites in the Proximal Promoter of the Human Vascular Endothelial Growth Factor Gene are Essential for Platelet-Derived Growth Factor-Induced Gene Expression” Oncogene 15:669-676 (1997).
Grand et al., PNAS USA (2004) 101(16):6140-6145.
Han et al., J. Am. Chem. Soc. 121:3561-3570 (1999).
Hans et al., TIBS (2000) 21:136-140.
Hurley et al., Abstracts of the American Chemical Society (2000) abstract PHYS-262 (abstract only).
International Search Report for PCT/US03/10658, mailed on Dec. 3, 2004, 6 pages.
Invitation to Pay Additional Fees for PCT/US03/10658, mailed on Aug. 24, 2004, 2 pages.
Jing et al., J. Biomol. Struct. Dyn. 15:573-585 (1997).
Jing et al., J. Biol. Chem. 273:34992-34999 (1998).
Kelly et al., J. Mol. Biol. 256:417-422 (1996).
Kettani et al., “A Two-Stranded Template-Based Approach to G (C-A) Triad Formation: Designing Novel Structural Elements into an Existing DNA Framework” J. Mol. Biol. 301:129-146 (2000).
Kim et al. Biochemistry (1998) 37:2299-2304.
Kuryavyi et al., “A Diamond-Shaped Zipper-like DNA Architecture Containing Triads Sandwiched between Mismatches and Tetrads” J. Mol. Biol. 295:455-469 (2000).
Kuryavyi et al., “A Double Chain Reversal Loop and Two Diagonal Loops Define the Architecture of a Unimolecular DNA Quadruplex Containing a Pair of Stacked G(syn) G(syn) G(anti) G(anti) Tetrads Flanked by a G (T-T) Triad and a T T T Triple” J. Mol. Biol. 310:181-194 (2001).
Lew et al., Proc. Natl. Acad. Sci. USA 97:12508-12512 (2000).
Li et al., Nucleic Acids Research (2005) 33(14):4649-4659.
Ma et al., “NM23-H1 and NM23-H2 Repress Transcriptional Activities of Nuclease-Hypersensitive Elements in the Platelet-Derived Growth Factor-A Promoter” J. Biol. Chem. 277(2):1560-1567 (2002).
Phan et al., Journal of the American Chemical Society (2004) 126(28):8710-8716.
Phan et al., Nature Chemical Biology (2005) 1(3):167-173.
Postel et al., J. Bioenerg. Biomembr. 32:277-284 (2000).
Rangan et al., J. Biol. Chem. (2001) 276(7):4640-4646.
Schultze et al., J. Mol. Biol. 235:1532-1547 (1994).
Seenisamy et al., Journal of the American Chemical Society (2004) 126(28):8702-8709.
Siddiqui-Jain et al.. PNAS USA (2002) 99(18):11593-11598.
Simonsson et al., J. Biol. Chem. (1999) 274(24):17379-17383.
Simonsson et al., Biochem. Biophys. Res. Comm. (2002) 290:11-15.
Sun et al., “Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound” J. Med. Chem. 40:2113-2116 (1997).
Supplementary European Search Report for EP 03 74 6640, mailed on Jun. 24, 2005, 3 pages.
Written Opinion for PCT/US03/10658, mailed on May 16, 2005, 6 pages.
Preliminary Amendment from U.S. Appl. No. 10/407,449, filed on Apr. 8, 2004.
Restriction Requirement from U.S. Appl. No. 10/407,449, mailed on Oct. 21, 2005.
Amendment in Response to Non-Final Office Action from U.S. Appl. No. 10/407/449, filed on Nov. 21, 2005.
Non-Final Office Action from U.S. Appl. No. 10/407,449, mailed on Dec. 20, 2005.
Amendment in Response to Non-Final Office Action from U.S. Appl. No. 10/407,449, filed on Jun. 20, 2006.
Final Office Action from U.S. Appl. No. 10/407,449, mailed on Jul. 14, 2006.
Preliminary Amendment and RCE from U.S. Appl. No. 10/407,449, filed on Dec. 1, 2006.
Non-Final Office Action from U.S. Appl. No. 10/407,449, mailed on Jan. 30, 2007.
Amendment in Response to Non-Final Office Action from U.S. Appl. No. 10/407,449, filed on Jul. 30, 2007.
Ebbinghaus Scot W.
Hurley Laurence H.
Memmott Regan
Siddiqui-Jain Adam
Arizona Board of Regents on behalf of the University of Arizona
Bertagna Angela
Horlick Kenneth R.
Morrison & Foerster / LLP
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