Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1993-01-22
1998-06-23
Spector, Lorraine M.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
4241391, 4241441, 4241921, 424810, 530350, 5303887, 530868, 435 697, A61K 39395, C07K 14705, C07K 1646
Patent
active
057701970
ABSTRACT:
The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
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Seed and Aruffo (Proc. Natl. Acad. Sci
Brady William
Damle Nitin K.
Ledbetter Jeffrey A.
Linsley Peter S.
Wallace Philip M.
Bristol--Myers Squibb Company
Spector Lorraine M.
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