Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Reexamination Certificate
2000-04-04
2001-09-04
Henley, III, Raymond (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
C514S002600, C514S159000, C514S356000, C514S725000
Reexamination Certificate
active
06284802
ABSTRACT:
TECHNICAL FIELD
The present invention relates to methods of regulating the condition of mammalian keratinous tissue using farnesol wherein the methods include: a) thickening skin and preventing and/or retarding atrophy in mammalian skin, b) preventing and/or retarding the appearance of spider vessels and/or red blotchiness on mammalian skin, c) preventing and/or retarding the appearance of dark circles under the eye of a mammalian, d) preventing and/or retarding sallowness of mammalian skin, e) preventing and/or retarding sagging of mammalian skin, f) softening and/or smoothing lips, hair and nails of a mammal, and g) preventing and/or relieving itch of mammalian skin. These methods are accomplished via the topical application of compositions containing farnesol to the keratinous tissue of a mammal needing such treatments.
BACKGROUND OF THE INVENTION
Currently, there are a number of personal care products which are available to consumers which are directed toward improving the health and physical appearance of human keratinous tissues such as the skin, hair, and nails which are equally useful for pet hygiene and grooming. The majority of these products are directed to delaying, minimizing or even eliminating skin wrinkling and other histological changes typically associated with the aging of skin or environmental damage to human skin.
Mammalian keratinous tissue, particularly human skin, is subjected to a variety of insults by both extrinsic and intrinsic factors. Such extrinsic factors include ultraviolet radiation, environmental pollution, wind, heat, infrared radiation, low humidity, harsh surfactants, abrasives, etc. Intrinsic factors, on the other hand, include chronological aging and other biochemical changes from within the skin. Whether extrinsic or intrinsic, these factors result in visible signs of skin damage. Typical skin damage includes thinning of the skin which occurs naturally as one ages. With such thinning, there is a reduction in the cells and blood vessels that supply the skin as well as a flattening of the dermal-epidermal junction which results in weaker mechanical resistance of this junction. See, for example, Oikarinen, “The Aging of Skin: Chronoaging Versus Photoaging,”
Photodermatol. Photoimmunol. Photomed
.. vol. 7, pp. 3-4, 1990. Other damage seen in aging or damaged skin includes spider vessels or red blotchiness, sallowness, sagging, under eye circles, and skin irritation which results in an itch. Additional damage incurred as a result of both external and internal factors includes damage to the keratinous tissue that constitutes lips, hair, and nails.
Therefore, there is a need for products and methods which seek to remedy these keratinous tissue conditions such that the condition of keratinous tissues like skin, hair, and nails are regulated.
It has now been surprisingly found that topical compositions which contain farnesol may be used to provide prophylactic as well as therapeutic treatments for these keratinous tissue conditions. For instance, it has been found that such compositions are useful for treating atrophy of the skin as well as sallowness, sagging, spider vessels, and itch relief. The compositions have also been found to be useful in smoothing and/or softening the keratinous tissue that constitutes the lips, hair, and nails.
SUMMARY OF THE INVENTION
The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a composition comprising:
a) a safe and effective amount of farnesol; and
b) a dermatologically-acceptable carrier for the farnesol.
In additional embodiments, the above composition is suitable for thickening skin and preventing and/or retarding atrophy of mammalian skin, preventing and/or retarding the appearance of spider vessels and/or red blotchiness on mammalian skin, preventing and/or retarding the appearance of dark circles under the eye of a mammal, preventing and/or retarding sallowness of mammalian skin, preventing and/or retarding sagging of mammalian skin, softening and/or smoothing lips, hair and nails of a mammal, and preventing and/or relieving itch of mammalian skin.
DETAILED DESCRIPTION OF THE INVENTION
All percentages and ratios used herein are by weight of the total composition and all measurements made are at 25° C., unless otherwise designated.
The compositions of the present invention can comprise, consist essentially of, or consist of, the essential components as well as optional ingredients described herein. As used herein, “consisting essentially of” means that the composition or component may include additional ingredients, but only if the additional ingredients do not materially alter the basic and novel characteristics of the claimed compositions or methods.
All publications cited herein are hereby incorporated by reference in their entirety.
The term “keratinous tissue,” as used herein, refers to keratin-containing layers disposed as the outermost protective covering of mammals (e.g., humans, dogs, cats, etc.) which includes, but is not limited to, skin, lips, hair, toenails, fingernails, cuticles, hooves, etc.
The term “topical application”, as used herein, means to apply or spread the compositions of the present invention onto the surface of the keratinous tissue.
The term “dermatologically-acceptable,” as used herein, means that the compositions or components thereof so described are suitable for use in contact with mammalian keratinous tissue without undue toxicity, incompatibility, instability, allergic response, and the like.
The term “safe and effective amount” as used herein means an amount of a compound or composition sufficient to significantly induce a positive benefit, preferably a positive keratinous tissue appearance or feel benefit, including independently or in combinations the benefits disclosed herein, but low enough to avoid serious side effects, i.e., to provide a reasonable benefit to risk ratio, within the scope of sound judgment of the skilled artisan.
The term “sagging” as used herein means the laxity, slackness, or the like condition of skin that occurs as a result of loss of, damage to, alterations to, and/or abnormalities in dermal elastin.
The terms “smoothing” and “softening” as used herein mean altering the surface of the keratinous tissue such that its tactile feel is improved.
The compositions of the present invention are useful for topical application and for regulating keratinous tissue condition. Regulation of keratinous tissue condition, namely mammalian and in particular human skin condition, is often required due to conditions which may be induced or caused by factors internal and/or external to the body. For instance, “regulating skin condition” includes prophylactically regulating and/or therapeutically regulating skin condition, and may involve one or more of the following benefits: thickening of skin (i.e., building the epidermis and/or dermis and/or sub-dermal (e.g., subcutaneous fat or muscle) layers of the skin and where applicable the keratinous layers of the nail and hair shaft) to reduce skin atrophy, increasing the convolution of the dermal-epidermal border (also known as the rete ridges), preventing loss of skin elasticity (loss, damage and/or inactivation of functional skin elastin) such as elastosis, sagging, loss of skin recoil from deformation; non-melanin skin discoloration such as under eye circles, blotching (e.g., uneven red coloration due to, e.g., rosacea) (hereinafter referred to as “red blotchiness”), sallowness (pale color), discoloration caused by telangiectasia or spider vessels. As used herein, prophylactically regulating skin condition includes delaying, minimizing and/or preventing visible and/or tactile discontinuities in skin (e.g., texture irregularities in the skin which may be detected visually or by feel). As used herein, therapeutically regulating skin condition includes ameliorating, e.g., diminishing, minimizing and/or effacing,
Bissett Donald Lynn
Jewell-Motz Elizabeth Ann
Henley III Raymond
Hilton Michael E.
Kendall Dara M.
The Procter & Gamble & Company
Tsuneki Fumiko
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