Methods for reducing tumor cell growth by using antibodies with

Details Methods for reducing tumor cell growth by using antibodies with Methods for reducing tumor cell growth by using antibodies with

1995-06-06

1998-12-08

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds specifically-identified oligosaccharide structure

4241431, 4241551, 4241741, 4241791, 4241811, 4241831, A61K 39395

Patent

active

058465359

ABSTRACT:
The subject invention relates to methods for reducing tumor cell growth in a mammal by administering compositions which include an antibody having the binding specificity of a monoclonal antibody selected from the group comprising one of those referred to as B1, B3 or B5 conjugated to a toxin, radionuclide or drug.

REFERENCES:
Kreitman, R.J. , et al., Abstract, "Properties of chimeric toxins with two recognition domains: interleukin 6 and transforming growth factor alpha at different locations in Pseudomonas exotoxin, " Bioconjug Chem, 3(1) :63-8 (1992 Jan-Feb).
Benhar, I., et al. , "Characterization of B1 (Fv) PE38 and B1 (dsFv) pE38: Single-Chain and Disulfide-stabilized Fv Immunotoxins with Increased Activity That Cause Complete Remissions of Established Human Carcinoma Xenografts in Nude Mice, " Clinical Cancer Resarch,vol. 1, pp. 1023-1029 (Sept. 1995).

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