Methods for reducing non-target retention of immunoconjugates an

Details Methods for reducing non-target retention of immunoconjugates an Methods for reducing non-target retention of immunoconjugates an

1994-11-08

1997-07-15

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

424 153, 424 9341, 4241781, 4241821, 424 94, 424 91, A61K 39395

Patent

active

056480598

ABSTRACT:
Methods for reducing non-target retention of active moieties associated with immunoconjugates and their metabolites, and more specifically, for reducing renal retention of such active moieties, are disclosed. Methods of the present invention comprise administering an effective amount of a non-target reduction moiety, such as lysine, in addition to a therapeutically or diagnostically effective amount of an immunoconjugate. The non-target reduction moiety localizes in the kidneys and inhibits renal retention and reabsorption of active moieties associated with immunoconjugates and their metabolites.

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