Methods for reducing immunogenicity of polypeptides

Details Methods for reducing immunogenicity of polypeptides Methods for reducing immunogenicity of polypeptides

2011-05-10

2011-05-10

Skelding, Zachary (Department: 1644)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S069700

Reexamination Certificate

active

07939295

ABSTRACT:
This invention relates to the fields of immunology and protein therapeutics. The therapeutic proteins are polypeptides to be administered especially to humans. The polypeptides are modified whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention therefor provides methods for the development of therapeutic polypeptides that are less immunogenic than any non-modified counterpart when used in vivo. The modifications used according to this invention relate, for example, to the introduction of protease cleavage sites, attachment of different molecules or insertion of non-natural amino acids.

REFERENCES:
patent: 6936249 (2005-08-01), Estell et al.
Weiss, A. in Fundamental Immunology 2nd Edition [1989], editor W. Paul. Raven Press, New York. pp. 359-384.
Rider et al., Molecular Immunology vol. 33, No. I/8, pp. 625-633.
Viret et al., Immunity, vol. 10, 559-568, May 1999.
Kropshofer et al., J. Exp. Med., vol. 175 Jun. 1992, 1799-1803.
Goldsby et al., Immunology, 5th ed., W.H. Freeman and Co., pp. 171-177 and 193-196.
Kropshofer et al., Proc. Natl. Acad. Sci. USA, vol. 90, pp. 403-407, Jan. 1993.

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