Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1988-03-11
1990-10-02
Weimar, Elizabeth C.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435212, 435219, 435815, 424 9464, C12N 964, A61K 37547
Patent
active
049607022
ABSTRACT:
Methods for recovering t-PA from a liquid medium are disclosed. The methods comprise contacting a liquid medium with at least one substrate capable of effecting a separation of intact t-PA from degraded t-PA thereafter recovering the intact t-PA free from other unrelated protein. The present invention also provides compounds produced by this method, compounds comprising intact one-chain t-PA and pharmaceutical compositions containing them and methods for using such compositions.
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Einarsson, M., et al., (1985), Biochem. Biophys. Acta 830, 1-10.
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Hoylaerts, et al., J. Biol. Chem., vol. 257, pp. 2912-2919, (1982).
Donner Peter A.
Glaser Charles
Morser Michael J.
Rice Craig
Codon
Patterson Charles L.
Weimar Elizabeth C.
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