Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1997-03-25
2000-06-27
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
534 10, 424 111, 424 165, A61K 5100, A61M 3614
Patent
active
060803843
ABSTRACT:
Novel methods for radiolabeling sulfhydryl group-bearing biomolecules, novel compositions useful for radiolabeling sulfhydryl group-bearing biomolecules, kits comprising such novel compositions and methods for imaging mammalian, preferably human, tissue employing radiolabelled biomolecules are described. The methods, compositions and kits of the present invention are useful for labeling sulfhydryl group-bearing biomolecules such as whole molecule proteins, protein fragments or peptides, in particular, monoclonal or polyclonal antibodies, and especially, antifibrin MH1 monoclonal antibody.
REFERENCES:
patent: Re35457 (1997-02-01), Rhodes
patent: Re35500 (1997-05-01), Rhodes
patent: 4305922 (1981-12-01), Rhodes
patent: 4311688 (1982-01-01), Burchiel et al.
patent: 4323546 (1982-04-01), Crockford et al.
patent: 4331647 (1982-05-01), Goldenberg
patent: 4348376 (1982-09-01), Goldenberg
patent: 4421735 (1983-12-01), Haber et al.
patent: 4424200 (1984-01-01), Crockford et al.
patent: 4472371 (1984-09-01), Burchiel et al.
patent: 4479930 (1984-10-01), Hnatowich
patent: 4647445 (1987-03-01), Lees
patent: 4652440 (1987-03-01), Paik et al.
patent: 4666698 (1987-05-01), Schwarz
patent: 4668503 (1987-05-01), Hnatowich
patent: 4670545 (1987-06-01), Fritzberg et al.
patent: 4877868 (1989-10-01), Reno et al.
patent: 5053493 (1991-10-01), Pak et al.
patent: 5061641 (1991-10-01), Shochat et al.
patent: 5078985 (1992-01-01), Rhodes
patent: 5080883 (1992-01-01), Lyle et al.
patent: 5102990 (1992-04-01), Rhodes
patent: 5116596 (1992-05-01), Bremer et al.
patent: 5164175 (1992-09-01), Bremer et al.
patent: 5177192 (1993-01-01), Pak et al.
patent: 5225180 (1993-06-01), Dean et al.
patent: 5277893 (1994-01-01), Rhodes
patent: 5317091 (1994-05-01), Subramanian
patent: 5328679 (1994-07-01), Hansen et al.
patent: 5334708 (1994-08-01), Chang et al.
patent: 5346687 (1994-09-01), Rhodes
Gargan and Bell, 1994, "Diagnostic Capacity of Tc-99m Mh1-Fab'0 for the Detection of Thrombi in Humans. A New Thrombus Specific Monoclonal Antibody Fragment," J. Nucl. Med. Abstract Book, Proceedings of the 41.sup.st Annual Meeting, Orlando, Florida, Jun. 5-8 35(5): Abstract No. 314.
Gargan et al., "Rapid Imaging of Pulmonary Emboli with Technetium 99M-Labeled Fragment of the Antifibrin Antibody, MH1," Thrombosis and Haemostasis, Abstract, XIVth Congress of the International Society on Thrombosis and Haemostasis, New York, New York, Jul. 4-9, p. 1356.
Pak et al., 1992, "An Instant Kit Method for Labeling Antimyosin Fab' with Technetium-99m: Evaluation in an Experimental Myocardial Infarct Model", J. Nucl. Med. 33:144-149.
Rhodes, 1991, "Direct Labeling of Proteins with .sup.99m Tc", Nucl. Med. Biol. 18:667-676.
Rhodes et al., 1986, "Technetium-99m Labeling of Murine Monoclonal Antibody Fragments", J. Nucl. Med. 27:685-693.
Schwarz and Steinstrasser, 1987, "A Novel Approach to Tc-99m-Labeled Monoclonal Antibodies", Society of Nuclear Medicine 28:721 (No. 695).
Thakur and DeFulvio, 1991, "Technetium-99m-Labeled Monoclonal Antibodies for Immunoscintigraphy", J. Immunol. Meth. 137:217-224.
Thakur et al., 1990, "Use of Ascorbic Acid(AA) for Direct TC-99 Labeling of Monoclonal Antibodies(MAbs)", Eur. J. Nucl Med. 16:392 (No. 8).
Verbruggen, 1990, "Radiopharmaceuticals: State of the Art", Eur. J. Nucl. Med. 17:346-364.
Wong et al., 1978, "A Rapid Chemical Method of Labeling Human Plasma Proteins with .sup.99m Tc-Pertechnetate at pH 7.4", Int. J. Appl. Radiation and Isotopes 29:251-253.
Bickerstaff and Zhou, 1993, "Protease Activity and Autodigestion (Autolysis) Assays Using Coomassie Blue Dye Binding", Anal. Biochem. 210:155-158.
Gargan et al., 1993, "Rapid Imaging of Pulmonary Emboli with a Technetium-99m-Labeled Fragment of the Antifibrin Antibody, MH1", THHADO 69:1356.
Griffiths et al., 1994, "Preparation of a Pure .sup.99m Tc-F(ab').sub.2 Radioimmunoconjugate by Direct Labeling Methods", Nucl. Med. Biol 21:649-655.
Griffiths et al., 1992, "Radiolabeling of Monoclonal Antibodies and Fragments with Technetium and Rhenium", Bioconjugate Chem. 3:91-99.
Mather and Ellison, 1990, "Reduction-Mediated Technetium-99m Labeling of Monoclonal Antibodies", J. Nucl. Med. 31:692-697.
Pak et al., 1989, "A Rapid and Efficient Method for Labeling IgG Antibodies with Tc-99m and Comparison to Tc-99m FAB' Antibody Fragments", J. Nucl. Med. 30:793 (No. 268).
Gargan Paul E.
Scheu John D.
American Biogenetic Sciences Inc.
Dees Jos,e G.
Jones Dameron
LandOfFree
Methods for radionuclide-labeling of biomolecules and kits utili does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for radionuclide-labeling of biomolecules and kits utili, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for radionuclide-labeling of biomolecules and kits utili will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1781769