Heating – Processes of heating or heater operation – Including apparatus purging – cleaning or accretion preventing
Reexamination Certificate
2007-11-13
2007-11-13
Saucier, Sandra E. (Department: 1651)
Heating
Processes of heating or heater operation
Including apparatus purging, cleaning or accretion preventing
C424S093730
Reexamination Certificate
active
10803109
ABSTRACT:
Methods are provided for quenching undesired side reactions of pathogen inactivating compounds in biological materials comprising red blood cells. In a particular embodiment, methods are provided for quenching undesired side reactions of a pathogen inactivating compound that includes a functional group which is, or which is capable of forming, an electrophilic group. In this embodiment, the material is treated with the pathogen inactivating compound and a quencher, wherein the quencher comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group. The electrophilic group on the pathogen inactivating compound is preferably a non-radical cationic group. In one embodiment, the pathogen inactivating compound includes a nucleic acid binding ligand and a mustard group, wherein the mustard group is capable of reacting in situ to form the electrophilic group. Preferred quenchers are thiols, such as glutathione. The methods permit inhibition of the modification of red blood cells in red blood cell containing materials during pathogen inactivation.
REFERENCES:
patent: 2402655 (1946-06-01), Peppel et al.
patent: 4252645 (1981-02-01), Marconi et al.
patent: 4337269 (1982-06-01), Berke et al.
patent: 4727027 (1988-02-01), Wiesehahn et al.
patent: 4748120 (1988-05-01), Wiesehahn et al.
patent: 4944920 (1990-07-01), Rubinstein
patent: 4971760 (1990-11-01), Rubinstein
patent: 5055485 (1991-10-01), Geacintov et al.
patent: 5094960 (1992-03-01), Bonomo
patent: 5120649 (1992-06-01), Horowitz et al.
patent: 5232844 (1993-08-01), Horowitz et al.
patent: 5281579 (1994-01-01), Estep
patent: 5418130 (1995-05-01), Platz et al.
patent: 5559250 (1996-09-01), Cook et al.
patent: 5587490 (1996-12-01), Goodrich, Jr. et al.
patent: 5591350 (1997-01-01), Piechocki et al.
patent: 5601730 (1997-02-01), Page et al.
patent: 5637451 (1997-06-01), Ben-Hur et al.
patent: 5658722 (1997-08-01), Margolis-Nunno et al.
patent: 5660731 (1997-08-01), Piechocki et al.
patent: 5691132 (1997-11-01), Wollowitz et al.
patent: 5753258 (1998-05-01), Schreier et al.
patent: 6093725 (2000-07-01), Cook et al.
patent: 6136586 (2000-10-01), Budowsky
patent: 6143490 (2000-11-01), Cook et al.
patent: 6150109 (2000-11-01), Edson et al.
patent: 6177441 (2001-01-01), Cook et al.
patent: 6270952 (2001-08-01), Cook et al.
patent: 6410219 (2002-06-01), Cook et al.
patent: 6709810 (2004-03-01), Cook et al.
patent: 2006/0115466 (2006-06-01), Stassinopoulos
patent: 0 352 076 (1990-01-01), None
patent: 0 352 076 (1990-01-01), None
patent: 0 457 196 (1991-11-01), None
patent: 0 641 796 (1995-03-01), None
patent: WO-95/00631 (1995-01-01), None
patent: WO-96/02838 (1996-02-01), None
patent: WO-96/09846 (1996-04-01), None
patent: WO-96/14737 (1996-05-01), None
patent: WO-96/39816 (1996-12-01), None
patent: WO-96/39818 (1996-12-01), None
patent: WO-96/40857 (1996-12-01), None
patent: WO-97/02028 (1997-01-01), None
patent: WO-97/07674 (1997-03-01), None
patent: WO-97/16966 (1997-05-01), None
patent: WO-97/18844 (1997-05-01), None
patent: WO-98/30545 (1998-07-01), None
patent: WO-99/34839 (1999-07-01), None
Aejmelaeus et al. (1996). “Is There an Unidentified Defense Mechanism Against Infection in Human Plasma,”FEBS Letters384:128-130.
Baxt et al. (1976). “Mechanisms of Vesicular Stomatitis Virus-Induced Cytopathic Effects,”Virology72:383-392.
Begleiter et al. “Chlorambucil in Chronic Lymphocytic Leukemia: Mechanism of Action,”Leukemia and Lymphoma23:187-201, (1996).
Beutler et al. (1982). “The Role of Bone Marrow Transplantation in the Treatment of Acute Leukemia in Remission,”Blood59:1115-1117.
Bolton et al. (1993). “Kinetic Analysis of the Reaction of Melphalan with Water, Phosphate, and Glutathione,”Drug Metab. Dispos. 21:986-9996.
Bolton et al. (1991). “Specificity of Isozymes of Murine Hepatic Gluthathione S-transferase for Conjugation of Glutathione with L-Phenylalanine Mustard,”Cancer Research51:2410-2415.
Bonadonna et al. (1964). “Protection Studies with Sodium Thiosulfate Against Methyl bis(J-Chloroethyl)amine Hydrochloride (HN2) and its Ethylenimonium Derivative,”Clin. Pharm.&Thera. 6:50-64.
Budowsky et al. (1996). “Principles of Selective Inactivation of the Viral Genome: Dependence of the Rate of Viral RNA Modification of the Number of Protonizable Groups in Ethyleneimine Oligomers,” (1996).Vaccine Res. 5:29-39.
Chong et al. (1990). “Evaluation of Thiol Borth for the Culture ofSalmonella typhiand other Bacteris fromBlood,”Yonsai Medical Journal31:163-167.
Colvin et al. (1993). “Role of Gulathione in Cellular Resistance to Alkylating Agents,”Adv. Enzyme Regul. 33:19-26.
Colvin et al. (1976). “Alkylating Properties of Phosphoramide Mustard,”Cancer Res. 36:1121-1126.
Davey et al. (1992). “The Effect of Prestorage Irradiation Posttransfusion Red Cell Survival,”Transfusion32:525-526.
Dern et al. (1967). “Studies on the Preservation of Human Blood. II. The Relationship of Erythrocyte Adenosine Triphosphate Levels and other In Vitro Measures to Red Cell Storageability,”J. Lab&Clin Med. 69:698-978.
Dirr et al. (1994). “X-Ray Crystal Structures of Cytosolic glutathione S-transferases Implactions for Protein Architecture, Substrate Recognition and Catalytic Function,”Eur. J. Biochem. 220:645-661.
Dirven et al. (1996). “Glutathione Conjugation of Alkylating Cytostatic Drugs with Nitrogen Mustard Group and the Role of Glutathione S-Transferases,”Chem. Res. Toxicol. 9:350-360.
Dirven et al. (1995). “Glutathione Conjugation of the Cytostatic Drug Ifosfamide and the Role of Human Glutathione S-transferases,”Chem. Res. Toxicol. 8:979-986.
Dirven et al. (1994). “The Interaction of Glutathione with 4-Hydroxycyclophosphamide and Phosporamide Mustard, Studies by 31P Nuclear Magnetic Resonance Spectroscopy,”Chem. Bio. Interact. 93:185-196.
Dirven et al. (1995). “The Role of Human Glutathione S-tranferases Isoenzymes in the Formation of Glutathione Conjugates of the Alkylating Cytostatic Drug Thiotepa,”Cancer Res. 55:1701-1706.
Dorr, R. T. (1991). “Chemoprotectants for Cancer Chemotherapy,”Semin. Oncol. 18:48-58.
Dulik et al. (1990). “Characterization of Glutathione Conjugates of Chlorambucil by Fast Atom Bombardment and Thermospray Liquid Chromatography/mass Spectrometry,”Biomed. Environ. Mass Spectrom. 19:248-252.
Dulik et al. (1986). “Characterization of Melphalan-Glutathione Adducts whose Formation is Catalyzed by Glutathione Transferases,”Biochem. Pharmacol. 35:3405-3409.
Dulik et al. (1987). “Conversion of Melphalan to 4-(Gluationyl)Phenyulalanine. A Novel Mechanism for Conjugation by Glutathione-S-transferases,”Drug Metab. Dispos. 15:195-199.
Fasth et al. (1973). “Protective Effect of Thiosulfate and metabolic Thiosulfate Precursors Against Toxicity of Nitrogen Mustard (HN2)”Biochem. Pharmacology22:1337-1351.
Gamcsik et al. (1997). “Kinetics of the Conjugation of Aniline Mustards with Glutathione and Thiosulfate,”Chem. Biol. Interact. 105:35-52.
Gao et al. (1991). “A Novel Cationic Liposome Reagent for Efficient Transfection of Mammalian Cells,”Biochem. Biophys. Res. Commun. 179:280-285.
Gao et al. (1993). “Cytoplasmic Expression of a Reporter Gene by Co-Delivery of T7 RNA Polymerase and T7 Promoter Sequence with Cationic Liposomes,”Nucleic Acids Res. 21:2867-2872.
Gao, et al. (1996). “Potentiation of Cationic Liposome-Mediated Gene Delivery by Polycations,”Biochemistry35:1027-1036.
Gourdie, T. A. (1991). “Synthesis and Evaluation of DNA-targeted Spatially Separated Bis(aniline mustards) as Potential Alkylating Agents with Enhanced DNA Cross-Linking Capability,”J. Med. Chem. 34(1):240-248.
Greenwalt et al. (1990). “Studies in Red Blood Cell Preservation: 3.A Phosphate-Ammonium-Adenine Addictive Solution,&#
Cook David
Stassinopoulos Adonis
Cerus Corporation
Saucier Sandra E.
LandOfFree
Methods for quenching pathogen inactivators in biological... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for quenching pathogen inactivators in biological..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for quenching pathogen inactivators in biological... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3873146