Methods for purifying adeno-associated virus

Details Methods for purifying adeno-associated virus Methods for purifying adeno-associated virus

2006-03-09

2009-12-01

Wessendorf, T. D. (Department: 1639)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

C424S204100, C424S184100, C514S002600

Reexamination Certificate

active

07625570

ABSTRACT:
The present invention provides methods of purifying adeno-associated virus (AAV) from compositions comprising AAV and at least a second, non-AAV; and methods for selectively inactivating a non-adeno-associated virus (non-AAV) in a liquid composition comprising AAV and the non-AAV. The methods generally involve subjecting the composition to hydrostatic pressure such that the non-AAV is selectively inactivated.

REFERENCES:
patent: 6143548 (2000-11-01), O'Riordan et al.
patent: 7056723 (2006-06-01), Heller et al.
Leonard et al., Enhanced Preparation of Adeno-Associated Viral Vectors by Using High Hydrostatic Pressure to Selectively Inactivate Helper Adenovirus, Biotechnology and Bioengineering, vol. 97, No. 5, Aug. 1, 2007, pp. 1170-1179.
Pontes L, F.L., Giongo V, Araujo JRV, Sepulveda A, Vilas-Boas M, Bonafe CFS, Silva JL,Pressure inactivation of animal viruses: potential biotechnological applications, inHigh Pressure Research in the Biosciences and Biotechnology, H. K, Editor. 1997, Leuven University Press.
Wilkinson N, Kurdziel AS, Langton S, Needs S, Cook N. Resistance of poliovirus to inactivation by high hydrostatic pressures. Innovative Food Science and Emerging Technologies. 2001. 2:95-98.

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