Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-03-23
1992-12-29
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530399, 530417, 530427, 530829, 530350, 5303873, 530412, 53038825, 424 858, 514 12, 514 8, 435 691, C07K 320, C07K 318
Patent
active
051752557
ABSTRACT:
Monoclonal antibodies specific for epitopes found on the B chain of PDGF (including v-sis, c-sis and platelet-derived forms) may be bound to columns and used for purification of rPDGF B. A solution containing a polypeptide possessing at least part of the structural conformation of rPDGF B is passed over such a column and the rPDGF B is bound to the antibody. The rPDGF B may then be eluted from the column to yield rPDGF B of greater than 95% purity as determined by SDS-PAGE.
REFERENCES:
patent: 4479896 (1984-10-01), Antoniades
Lars et al., Chem. Abst., 109, 155(1988), entry No. 6724b.
Deuel et al, The Journal of Biological Chemistry, vol. 256, No. 17, 8896-8899(1981).
Nicolson Margery A.
Thomason Arlen R.
Abers Julia E.
Amgen Inc.
Moezie F. T.
Odre Steven M.
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