Methods for providing testosterone and optionally estrogen repla

Details Methods for providing testosterone and optionally estrogen repla Methods for providing testosterone and optionally estrogen repla

1993-08-03

1995-10-24

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424448, A61F 1300

Patent

active

054608201

ABSTRACT:
A method of providing testosterone replacement therapy to a woman in need of such therapy comprising applying a testosterone-delivering patch to the skin of said woman which patch transdermally delivers 50 to 500 .mu.g/day of testosterone to the woman.

REFERENCES:
patent: 5023084 (1991-06-01), Chien
patent: 5152997 (1992-10-01), Ebert et al.
Urman et al., "Elevated serum testosterone, hirsutism, and virilism associated with combined and androgen-estrogen hormone replacement therapy" Obstetrics & Gynecology (1991) 77:595-598.
Sherwin, B. B., et al., "Sex steroids and affect in the surgical menopause: A double blind, cross-over study" Psychoneuroendocrinology (1985) 10(3):325.gtoreq.335.
Sherwin, B. B., et al., "Androgen enhances sexual motivation in females: A prospective, crossover study of sex steroid administration in the surgical menopause" Psychosomatic Medicine (1985) 47(4):339-351.
Sherwin, B. B., et al., "Differential symptom response to parenteral estrogen and/or androgen administration in the surgical menopause" American Journal of Obstetrics and Gynecology (1985) 151(2):153-160.
Yu, J-W., et al., "Transdermal dual controlled delivery of testosterone and estradiol: (I) Impact of system design" Drug Develoment and Industrial Pharmacy (1991) 17(14):1883-1904.
Yu, J-W., et al., "Transdermal dual controlled delivery of testosterone and estradiol: (II) Enhanced skin permeability and membrane-moderated delivery" Drug Development and Industrial Pharmacy (1991) 17(14):1905-1930.

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