Methods for protecting tissues and organs from ischemic damage

Details Methods for protecting tissues and organs from ischemic damage Methods for protecting tissues and organs from ischemic damage

1994-03-17

1996-11-12

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424451, 424464, 424489, 514936, 604 51, A61F 202, A61K 948, A61K 920, A61K 914

Patent

active

055737722

ABSTRACT:
Methods for protecting tissues and organs including the heart central nervous system, and kidney from ischemic damage are described and claimed based upon the recognition that protection against infarction is mediated by A3 rather than A1 adenosine receptors, as was previously thought, and that the receptor mediating protection in other organs and tissues has not been defined. Methods for selectively stimulating A3 adenosine receptors are described and claimed, as such selection is shown to prevent or substantially reduce cell death resulting from ischemia with or without reperfusion in humans. According to this invention, the A3 adenosine receptor is selectively stimulated by administering a compound which is an A3 adenosine receptor-selective agonist. Prevention of tissue death is also achieved by administering a compound which is a non-selective adenosine receptor agonist together with compounds that act as antagonists to the A1 and A2 adenosine receptor.

REFERENCES:
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