Methods for protecting cells from amyloid toxicity and for...

Details Methods for protecting cells from amyloid toxicity and for... Methods for protecting cells from amyloid toxicity and for...

2006-05-30

2006-05-30

Weddington, Kevin E. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S456000, C514S457000, C514S866000

Reexamination Certificate

active

07053116

ABSTRACT:
In accordance with the present invention, there are provided novel methods of blocking amyloid protein toxicity in cells using polycylic compounds. Also provided are novel methods of decreasing amyloid protein production in cells and methods of inhibiting cell death. Invention methods can be used to prevent and treat a diverse class of disease conditions, known as amyloidoses, which are all related to the occurrence of amyloid protein deposits. Invention methods further provide methods of identifying compounds that can block amyloid toxicity or block the amyloid protein induced inhibition of MMT reduction.

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Liu et al., “Mechanism of Cellular 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolim Bromide (MTT) Reduction”,Journal of Neurochemistry, vol. 69, No. 2, pp. 581-593 (1997).
Liu et al., “Cytotoxic Amyloid Peptides Inhibit Cellular 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) Reduction by Enhancing MTT Formazan Exocytosis”,Journal of Neurochemistry, vol. 69, No. 6, pp. 2285-2293 (1997).
Liu et al., “Steroid Hormones Block Amyloid Fibril-Induced 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) Formazan Exocytosis: Relationship to Neurotoxicity”,Journal of Neurochemistry, vol. 71, No. 6, pp. 2322-2329 (1998).

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