Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Oxidoreductases
Patent
1998-10-02
2000-08-15
Achutamurthy, Ponnathapu
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Oxidoreductases
435189, 4352523, 4353201, 424 941, A61K 3844, C12N 902, C12N 1553, C12N 1585
Patent
active
061032301
ABSTRACT:
The present invention provides a method of promoting the closure of a wound in a patient. This method involves transferring exogenous iNOS to the region of the wound whereby a product of iNOS is produced in the region of the wound to promote the closure of the wound. The present invention also provides a method of transplanting a graft into a patient, which method involves transferring a vector comprising an iNOS expression cassette to cells associated with the graft and surgically incorporating the graft tissue into the patient. Upon expression of iNOS within the patient, a product of iNOS is produced in the region of the graft to attenuate vasculopathy in the region of the graft.
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Billiar Timothy R.
Edington Howard David James
Geller David A.
Shears, II Larry L.
Tzeng Edith
Achutamurthy Ponnathapu
Moore William W
University of Pittsburgh of the Commonwealth System of Higher Ed
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