Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Oxidoreductases
Patent
1996-11-08
1998-11-03
Jacobson, Dian C.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Oxidoreductases
435189, 424 941, A61K 3844, C12N 902
Patent
active
058304614
ABSTRACT:
The present invention provides a method of promoting the closure of a wound in a patient. This method involves transferring exogenous iNOS to the region of the wound whereby a product of iNOS is produced in the region of the wound to promote the closure of the wound.
REFERENCES:
patent: 4840940 (1989-06-01), Sottiuri
patent: 5132407 (1992-07-01), Stuehr et al.
patent: 5252479 (1993-10-01), Srivastava
patent: 5304121 (1994-04-01), Shahatjian
patent: 5328470 (1994-07-01), Nabel et al.
patent: 5428070 (1995-06-01), Cooke et al.
Shabani et al., Wound Repair and Regeneration, 4(3,) 353-362 (1996).
Shears et al., Proceedings for the 51.sup.st Annual Sessions of the Owen H. angensteen Surgical Forum, 451-45 (1996).
Von Der Leyen et al., Proceeding of the National Academy of Science USA, 92, 1137-1141 (1995).
Tzeng et al., Proceeding of the National Academy of Science USA, 92, 11771-11775 (1995).
Shears et al., Journal of Clinical Investigation, 100(8) 2035-2042 (1997).
Albina et al., J. Immunol., 150(11), 5080-5085 (1993).
Billiar, et al., Biochem. Biophys. Res. Comm., 168, 1034-1040 (1990).
Billiar, et al., J. Leuk. Biol., 48, 565-569 (1990).
Bredt, et al., Nature, 351, 714-718 (1991).
Bucala, et al., J. Clin. Invest. 87, 432-438 (1991).
Busse and Mulsch, FEBS Letters, 265, 133-136 (1990).
Charles et al., Proc. Natl. Acad. Sci. USA, 90, 11419-11423 (1993).
Chester, et al., Lancet, 336, 897-900 (1990).
Chenais et al., Biochem. Biophys. Res. Commun., 196, 1558-63 (1993).
Chin, et al., J. Clin Invest., 89, 10-18 (1992).
Curran, et al., J. Exp. Med., 170, 1769-1774 (1989).
Danos and Mulligan, Proc. Natl. Acad. Sci. USA, 85, 6460-6464 (1988).
Draiper, et al., Res. Immunol., 142, 553-602 (1991).
Gao and Huang, Biochm. Biophys. Res. Comm., 179, 280-285 (1991).
Geller, et al., Proc. Natl. Acad. Sci. USA, 90, 3491-3495 (1993).
Granger, et al., J. Clin. Invest., 81, 1129-1136 (1988).
Green, et al., J. Leuk. Biol., 50, 93-103 (1991).
Gross, et al., Biochem. Biophys. Res. Comm., 178, 823-829 (1991).
Harbrecht, et al., J. Leuk. Biol., 52, 390-394(??).
Hibbs, et al., J. Immun., 138, 550-565 (1987).
Hibbs, et al., Science, 235, 473-476 (1987).
Ignarro, et al. Proc. Natl. Acad. Sci. USA, 84, 9265-9269 (1987).
Janssens, et al., J. Biol. Chem., 267, 14519-14522 (1992).
Kilbourn, et al., Proc. Natl. Acad. Sci. USA, 87, 3629-3632 (1990).
Lowenstein, et al., Proc. Natl. Acad. Sci. USA, 89, 6711-6715 (1992).
Lyons, et al., J. Biol. Chem., 267, 6370-6374 (1992).
Mannino and Gould-Fogerite, BioTechniques, 6, 682-690 (1988).
Mardsen, et al., FEBS Letters, 307, 287-293 (1992).
McNamara, et al., Biochm. Biophys. Res. Comm., 193(1), 291-296 (1993).
Miller, Current Topics in Microbiology and Immunology, 158, 1-24 (1992).
Moncada, et al., Pharmacological Reviews, 43, 109-142 (1991).
Muzyczka, Current Topics in Microbiology and Immunology, 158, 97-129 (1992).
Nabel, et al., Science, 244, 1342-1344 (1989).
Nabel, et al., Science, 249, 1285-1288 (1990).
Nakayama, et al., Am. J. Respir. Cell Mol. Biol. , 7, 471-476 (1992).
Nunokawa and Tanaka, Biochem. Biophys. Res. Comm., 188, 409-415, (1992).
Nussler, et al. FASEB J. , 6, 5:A1834#5200 (1992).
Nussler, et al., J. Exp. Med., 176, 261 (1992).
Palmer, et al., Nature, 327, 524-525 (1987).
Radomski, et al., Br. J. Pharmac., 92, 639-646 (1987).
Rosenberg, Human Gene Therapy, 3, 57-73 (1992).
Stribling et al., Proc. Natl. Acad. Sci. USA, 89, 11277-11281 (1992).
Stuehr et al., J. Biol. Chem., 266, 6259-6263 (1991).
von der Leven, et al., FASEB J., 8, A802 #4651 (1994).
Werner-Felmayer, et al., J. Exp. Med., 172, 1599-1607 (1990).
Wilson, et al. Science, 244, 1344-1346 (1989).
Xie, et al., Science, 256, 225-228 (1992).
Zwiebel, et al., Science, 243, 220-22 (1989).
Billiar Timothy R.
Edington Howard David James
Geller David A.
Shears, II Larry L.
Tzeng Edith
Jacobson Dian C.
University of Pittsburgh of the Commonwealth System of Higher Ed
LandOfFree
Methods for promoting wound healing and treating transplant-asso does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for promoting wound healing and treating transplant-asso, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for promoting wound healing and treating transplant-asso will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-686678