Methods for promoting growth and survival of...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

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C424S520000, C530S300000

Reexamination Certificate

active

08071368

ABSTRACT:
The present invention relates to compositions containing unacylated ghrelin and derivatives thereof and their uses in the control of glycemia in ageing patients, GH deficient patients, diabetic patients and obese patients.

REFERENCES:
patent: 7825090 (2010-11-01), Ghigo et al.
patent: 2470235 (2003-06-01), None
patent: 2471879 (2003-11-01), None
patent: 2543507 (2005-05-01), None
patent: 01/56592 (2001-08-01), None
patent: 01/87335 (2001-11-01), None
patent: 01/92292 (2001-12-01), None
patent: 02/060472 (2002-08-01), None
patent: 03/051389 (2003-06-01), None
patent: WO 2005/039624 (2005-05-01), None
patent: 2006/045319 (2006-05-01), None
patent: WO 2007/126792 (2007-11-01), None
patent: WO 2008/145749 (2008-12-01), None
Baldanzi et al., Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT, J. Cell Biol., 159:1029-1037 (2002).
Li et al., Cardioprotective effects of ghrelin and des-ghrelin on myocardial injury induced by isoproterenol in rats, Acta Pharmacologia Sinica, 27:527-535 (2006).
Office Action issued on Oct. 1, 2010 in connection with U.S. Appl. No. 12/130,615, 8 pp.
Office Action issued on Apr. 29, 2010 in connection with U.S. Appl. No. 12/130,615, 11 pp.
Office Action issued on Oct. 16, 2009 in connection with U.S. Appl. No. 12/130,615, 18 pp.
International Search Report mailed on Jan. 25, 2010 in connection with International Patent Application PCT/EP2009/057263 (WO 2009/150214 A3).
Granata, et al., Acylated and Unacylated Ghrelin Promote Proliferaion and Inhibit Apoptosis of Pancreatic beta Cells and Human Islets: Involvement of 3′, 5′—Cyclic Adenosine Moriophosphate/Protein Kinase A. Extracellular Signal-Regulated kinase 1/2, and Phosphatidyl Inositol 3-Kinase/Akt Signaling, Endocrinology, vol. 148, No. 2, pp. 512-529, 2007.
Granata, et al., Acylated and unacylated ghrelin promote proliferation and inhibit serum stravation- and cytokine-induced apoptosis of pancreatic beta cells through cAMP/PKA, ERK 1/2 and P13K/Akt, Abstract and poster presented at Meeting of the Endocrine Society, Boston, from Jun. 24, 2006.
Prodam, et al., Unacylated Ghrelin (UAG) Enhances the Early Insulin Response to Meal, Improves Glucose Metabolism and Decreases Free Fatty Acids Levels in Health Volunteers, Abstract and poster presented at European Congress of Endocrinology, Budapest, from Apr. 28, 2007 to May 2, 2007.
Cassoni, et al., “Identification, Characterization, and Biological Activity of Specific Receptors for Natural (Ghrelin) and Synthetic Growth Hormone Secretagogues and Analogs in Human Breast Carcinomas and Cell Lines,” The Journal of Clinical Endocrinology & Metabolism, vol. 86. No. 4, pp. 1738-1744, 2001.
Toshinai, et al., “Upregulation of Ghrelin Expression in the Stomach upon Fasting, Insulin-Induced Hypoglycemia, and Leptin Administration,” Biochemical and Biophysical Research Communications, vol. 281, pp. 1220-1225, 2001.
Mickle and Cutting, “Genotype-Phenotype Relationships in Cystic Fibrosis,” Med. Clin. North Am., 2000, vol. 84(3), p. 597-607.
Adelhorst, et al., “Structure-Activity Studies of Glucagon-like Peptide-1,” J. Biol. Chem. 269: 6275-6278, 1994.
Marzullo, et al., “The Relationship between Active Ghrelin Levels and Human Obesity Involves Alterations in Resting Energy Expenditure,” J. Clin. Endocr. Metab. 89: 936-939, 2004.
Broglio, et al., “Non-Acylated Ghrelin Counteracts the Metabolic but not the Neuroendocrine Response to Acylated Ghrelin in Humans,” The Journal of Clinical Endocrinology & Metabolism, vol. 69, No. 6, pp. 3062-3065, Jun. 2004.
Poykko, et al., “Low Plasma Ghrelin is Associated With Insulin Resistance, Hypertension, and the Prevalence of Type 2 Diabetes,” Diabetes, vol. 52, pp. 2546-2553, Oct. 2003.
Soares, Joao-Bruno et al., “Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle,” Peptides, vol. 29, No. 7, Jul. 2008, pp. 1255-1270.

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