Methods for profiling mRNA expression in neurites

Details Methods for profiling mRNA expression in neurites Methods for profiling mRNA expression in neurites

1994-11-03

1998-03-03

Myers, Carla J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 435 9121, 435 9151, 536 235, 536 2431, 935 17, 935 18, 935 77, 935 78, C12Q 168, C07H 2104, C12P 1934

Patent

active

057232903

ABSTRACT:
A method of identifying neurite cDNA clones by determining and comparing mRNA expression in selected neurites is provided. cDNA clones identified by this method are also provided. In addition, methods of profiling mRNA expression and diagnosing and treating conditions associated with a pattern of mRNA expression by determining an mRNA expression profile are provided.

REFERENCES:
Craig et al., "The Distribution of Glutamate Receptors in Cultured Rat Hippocampal Neurons: Postsynaptic Clustering of AMPA-Selective Subunits," Neuron 1993, 10, 1055, 1068.
Chicurel et al., "mRNA at the Synapse: Analysis of a Synaptosomal Preparation Enriched in Hippocampal Dendritic Spines," J. Neurosci 1993, 13, 4054-4063.
Liang et al., "Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction," Science 1993, 257, 967-971.
Gennaro, A., Ed., Remington's Pharmaceutical Sciences, 18th Ed., 1990.
Eberwine et al, Proceedings National Academy of Sciences, USA (1992) 89: 3010-3014.

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