Methods for production of hyaluronic acid, and isolated...

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

Reexamination Certificate

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C435S041000, C435S084000, C435S101000, C435S252100, C435S441000, C435S444000, C514S054000

Reexamination Certificate

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07323329

ABSTRACT:
Isolated strains of supercapsulatedstreptococciband at a density of no greater than 1.03 g/cm3in a Percoll gradient and are capable of producing hyaluronic acid with molecular weight exceeding 6 million Da. Methods of producing high molecular weight hyaluronic acid employ a supercapsulated strain ofstreptococcuswhich bands at a density of no greater than 1.03 g/cm3in a Percoll gradient. Methods of selectingstreptococcusstrains capable of producing hyaluronic acid with a molecular weight exceeding 6 million Da comprise, inter alia, cultivating supercapsulated strains ofstreptococciwhich band at a density of no greater than 1.03 g/cm3in a Percoll gradient.

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