Methods for producing ribose-1-phosphoric acid and ribavirin

Details Methods for producing ribose-1-phosphoric acid and ribavirin Methods for producing ribose-1-phosphoric acid and ribavirin

1989-09-15

1990-11-06

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Process involving micro-organisms of different genera in the...

435 85, 435 87, 435847, 435852, C12P 1938, C12P 3900, C12R 107, C12R 122

Patent

active

049686062

ABSTRACT:
The present invention relates to methods for producing ribavirin utilizing microorganisms and a method for producing ribose-1-phosphoric acid which is a precursor of ribavirin. The methods involve contacting certain microorganisms with orotidine, orotidic acid, or salts thereof, and inorganic phosphoric acid or a salt thereof (to produce ribose-1-phosphoric acid), and further with 1,2,4-triazole-3-carboxamide or a salt thereof (to produce ribavirin) in an aqueous solvent.

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