Methods for producing recombinant mammalian cells harboring a ye

Details Methods for producing recombinant mammalian cells harboring a ye Methods for producing recombinant mammalian cells harboring a ye

1994-01-25

1999-11-09

Ketter, James

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4351723, C12Q 168

Patent

active

059811757

ABSTRACT:
The present invention provides methods and compositions for transferring large transgene polynucleotides and unlinked selectable marker polynucleotides into eukaryotic cells by a novel method designated co-lipofection. The methods and compositions of the invention are used to produce novel transgenic non-human animals harboring large transgenes, such as a transgene comprising a human APP gene or human immunoglobulin gene.

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