Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2007-08-30
2009-06-09
Gonzalez, Porfirio Nazario (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C560S039000, C564S134000
Reexamination Certificate
active
07544833
ABSTRACT:
Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid.
REFERENCES:
patent: 3840570 (1974-10-01), Julian
patent: 4927814 (1990-05-01), Gall et al.
patent: 5650386 (1997-07-01), Leone-Bay et al.
patent: WO 00/46182 (2000-08-01), None
patent: WO 00/59863 (2000-10-01), None
patent: WO 01/70219 (2001-09-01), None
Bay William Elliott
Bernadino Joseph Norman
Klein George Frederick
Ren Yi
Zhang Ping-sheng
Cutliff Yaté K.
Emisphere Technologies Inc.
Gonzalez Porfirio Nazario
Hoffmann-La Roche Inc.
Johnston George W.
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