Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-10-05
2000-02-15
Budens, Robert D.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4241331, 4241341, 4241351, 4241361, 435451, 435452, 435455, 4352523, 43525233, 5303873, 536 2353, A61K 39395, C07K 1600, C07K 1644, C12P 2108, C07H 2104
Patent
active
060251654
ABSTRACT:
Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypeptide chain molecules, and production of multivalent proteins from purified monomers. Production of multivalent proteins may occur by a concentration-dependent association of monomeric proteins, or by rearrangement of regions involving dissociation followed by reassociation of different regions. Bivalent proteins, including homobivalent and heterobivalent proteins, are made in the present invention. Genetic sequences coding for bivalent single-chain antigen-binding proteins are disclosed. Uses include all those appropriate for monoclonal and polyclonal antibodies and fragments thereof, including use as a bispecific antigen-binding molecule.
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Bird Robert E.
Filpula David
Hardman Karl D.
Rollence Michele
Whitlow Marc D.
Budens Robert D.
Enzon Inc.
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