Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-06-09
2000-07-04
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 697, 4352521, 4352528, 4353201, 536 231, 536 234, C12P 2106, C12N 112, C12N 500, C07H 2102
Patent
active
060837152
ABSTRACT:
Disclosed are methods and compositions for producing heterologous disulfide bond containing polypeptides in bacterial cells. In preferred embodiments the methods involve co-expression of a prokaryotic disulfide isomerase, such as DsbC or DsbG and a gene encoding a recombinant eukaryotic polypeptide. Exemplary polypeptides disclosed include tissue plasminogen activator.
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Bessette Paul
Georgiou George
Oiu Ji
Swartz James
Board of Regents , The University of Texas System
Genentech Inc.
Patterson Jr. Charles L.
Tung Peter P.
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