Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1997-05-29
2000-04-18
Naff, David M.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
424 931, 4241841, 4242341, 435822, 435960, 435961, 435975, A01N 6300, A61K 3900, C12N 100, C12N 112
Patent
active
060514167
ABSTRACT:
Methods using in vitro processes are disclosed for inducing or enhancing expression of enteric bacterial antigens or virulence factors. The methods, therefore, produce antigenically enhanced enteric bacteria. Also methods for using the antigenically enhanced bacteria are also disclosed, as well as vaccines containing the enteric bacteria. Specifically a whole enteric bacterium or components thereof are provided by Helicobacter species. Also there are other enteric bacteria which are useful for the disclosed invention; such as Campylobacter jejuni.
REFERENCES:
patent: 4923801 (1990-05-01), Marshall et al.
patent: 5262156 (1993-11-01), Alemohammad
patent: 5403924 (1995-04-01), Cover et al.
patent: 5434253 (1995-07-01), Thompson et al.
patent: 5459041 (1995-10-01), Blaser
patent: 5527678 (1996-06-01), Blaser et al.
patent: 5538729 (1996-07-01), Czinn et al.
patent: 5610060 (1997-03-01), Ward et al.
patent: 5681736 (1997-10-01), Pace et al.
Andrews & Maurelli, 1992, mxiA of Shigella flexneri 2a, which facilitates export of invasion plasmid antigens, encodes a homolog of the low-calcium-response protein, LcrD, of Yersinia pestis. Infect. Immun. 60:3287-3295.
Baqar et al., 1995, "Immunogenicity and protective efficacy of a prototype Campylobacter killed whole-cell vaccine in mice." Infect. Immun. 63:3731-3735.
Bell & Manning, 1990, "A domestic ferret model of immunity to Campylobacter jejuni-induced enteric disease." Infect. Immun. 58:1848-1852.
Blaser & Gotschilch, 1990, "Surface array protein of Campylobacter fetus." J. Biol. Chem. 265:14529-14535.
Caldwell et al., 1983, "Simple adult rabbit model for Campylobacter jejuni enteritis." Infect. Immun. 42:1176-1182.
Chen et al., 1992, "Immunization against gastric helicobacter infection in a mouse/Heliocobacter felis model." Lancet 339:1120-1121.
Durham et al., 1994, 94th Am. Soc. Microbiol. Abstract P-36, p. 386.
Field et al., 1993, "Characteristics of an avirulent Campylobacter jejuni strain and its virulence-enhanced variants." J. Med. Microbiol. 38:293-300.
Gilmour et al., 1991, "Vaccine containing iron-regulated proteins of Pasteurella haemolytica A2 enhances protection against experimental pasteurellosis in lambs." Vaccine 9:137-140.
Grant et al., 1993, "Role of flagella in adherence, internalization, and translocation of Campylobacter jejuni in nonpolarized and polarized epithelial cell cultures." Infect. Immun. 61:1764-1771.
Hale et al., 1985, "Identification and antigenic characterization of virulence-associated, plasmid-coded proteins of Shigella spp. and enteroinvasive Escherichia coli." Infect. Immun. 50:620-629.
High et al., 1992, "IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole." EMBO J. 11:1991-1999.
Konkel et al., 1993, J. Infect. Dis. 168:948-954.
Levenson et al., 1988, "Parental immunization with Shigella ribosomal vaccine elicits local Ig A response and primes for mucosal memory." Arch. Allergy Appl. Immunol. 87:25-31.
J. Mekalanos, 1992 J. Bacteriol. 174:1-7.
Panigrahi et al., 1992, Infect. Immun. 60:4938-4944.
Pavlovskis et al., 1992, "Significance of flagella in colonization resistance of rabbits immunized with Campylobacter spp." Infect. Immun. 59:2259-2264.
S.M. Payne, 1989, Mol. MicroBiol. 3:1301-1306.
Payne & Finkelstein, 1977, "Imferon agar: Improved medium for isolation of pathogenic Nesseria." J. Clin. Microbiol. 6:293-297.
Pope & Payne, 1993, 93rd Am. Soc. Microbiol. Abstract B-147.
Robbins et al., 1991, "O-Specific side-chain toxin-protein conjugates as parentaeral vaccines for the prevention of shigellosis and related diseases." Rev. Inf. Dis. 13:S362-365.
H.W. Yoder, 1989, "Congo red binding by Escherichia coli isolates from chickens." Avian Dis. 33:502-505.
Czinn and Nedrud, 1991, Infection and Immunity 59:2359-2363.
Sigma Chemical Co. Catalog, p. 420.
Sigma Chemical Co. Catalog, p. 104.
Clements et al., "Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens," Vaccine, 6:269-275, Jun. 1988.
Czinn et al., "Oral Immunization Protects Germ-Free mice Against Infection From Helicobacter Felis," Gut, vol. 102(4), Part 2 Suppl., Apr. 1992.
Czinn et al., "Oral Immunization Against Helicobacter pylori," Infection and Immunity, 59:2359-2363, 1991.
Czinn et al., "Protection of germ-free mice after infection by Helicobacter felis after active oral or passive IgA immunization," Vaccine 11:637-642, 1993.
Doig et al., "Production of a Conserved Adhesin by the Human Gastroduodenal Pathogen Helicobacter pylori," Journal of Bacteriology, 174:2539-2547, Apr. 1992.
Ferrero et al., The Importance of Urease in Acid Protection for the Gastric-colonising Bacteria Helicobacter pylori and Helicobacter felis sp. nov., Microbial Ecology in Health and Disease, 4:121-134, 1991.
Heap et al., Immunisation and Gastric Colonisation with Helicobacter Felis, VIth International Workshop on Campylobacter, Hexicobacter and Related Organisms, Sydney, New South Wales, Australia, Oct. 7-10, 1991, Microb Ecol. Health Dis. 4, 1991.
Mills et al., "Lipopolysaccharde Antigens of Helicobacter Pylori," VIth International Workshop on Campylobacter Helicobacter and Related Organisms, Sydney, New South Wales, Australia, Oct. 7-10, 1991, Microb Ecol. Health Dis. 4, 1991.
Pappo et al., "Effect of Oral Immunization with Recombinant Urease on Murine Helicobacter felis Gastritis," Infection and Immunity, 53:1246-1252, Apr. 1995.
Pavlovskis et al., "Adjuvant Effect of Escherichia coli Heat-Labile Enterotoxin on Host Immune Response Following Vaccination with Non-Viable Campylobacter Antigens," VIth International Workshop on Campylobacter Helicobacter and Related Organisms, Sydney, New South Wales, Australia, Oct. 7-10, 1991, Microb Ecol. Health Dis. 4, 1991.
Rappuoli et al., "Development of a vaccine against Helicobacter pylori: a short overview," European Journal of Gastroenterology & Hepatology, 5:576-578, 1993.
Frey Steven Michael
Pace John Lee
Walker Richard Ives
Antex Biologics Inc.
Naff David M.
Ware Deborah K.
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