Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2008-12-09
2010-02-23
Graser, Jennifer E (Department: 1645)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069300, C435S069700, C435S071100, C435S243000, C435S252100, C435S252300, C435S252310
Reexamination Certificate
active
07666625
ABSTRACT:
The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parentBacilluscell under conditions conducive for the production of the heterologous biological substance, wherein (i) the mutant cell comprises a first nucleic acid sequence directing synthesis of the heterologous biological substance and a second nucleic acid sequence comprising a modification of at least one of the genes cypX and yvmC, which are involved in the production of a red pigment, and (ii) the mutant cell is deficient in the production of the red pigment compared to the parentBacilluscell when cultivated under the same conditions; and (b) recovering the heterologous biological substance from the cultivation medium. The present invention also relates to mutants ofBacilluscells and methods for producing the mutants.
REFERENCES:
Bowie et al., Science 247:1306-1310.
Kuffer et al., 1967, Archiv für Mikrobiologic 56: 9-21.
MacDonald, 1967, Canadian Journal of Microbiology 13: 17-20.
Uffen and Canale-Parola, 1972, Journal of Bacteriology 111: 86-93.
E. Canale-Parola, 1963, Archiv für Mikrobiologic 46: 414-427.
Behr Regine
Sloma Alan
Sternberg David
Sternberg, legal representative Linda
Tang Maria
Graser Jennifer E
Novozymes, Inc.
Starnes Robert L.
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