Methods for producing antibody libraries using universal or rand

Details Methods for producing antibody libraries using universal or rand Methods for producing antibody libraries using universal or rand

1997-09-16

2000-08-01

Saunders, David

Chemistry: analytical and immunological testing

Process or composition for determination of physical state...

Corrosion resistance or power

536 2353, 536 2433, C12Q 168, C07H 2104

Patent

active

060965517

ABSTRACT:
The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles comprising the library. The invention also describes oligonucleotides useful for increasing the library diversity, and universal light chains useful in the library production methods.

REFERENCES:
Cumano, A and Rajewsky, K. Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP. EMBO J. 3(10):2459-2468, 1986.
Paul, W.E. Fundamental Immunology, Fourth Editon, Lippincott-Raven Pub. New York, pp. 41 and 42, 1999.

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