Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-06-27
2006-06-27
Schwadron, Ronald D. (Department: 1644)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069200, C435S091200, C435S462000, C435S471000, C435S069100, C530S387300, C536S023530, C536S024300, C536S024330
Reexamination Certificate
active
07067284
ABSTRACT:
The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles comprising the library. The invention also describes oligonucleotides useful for increasing the library diversity, and universal light chains useful in the library production methods.
REFERENCES:
patent: 5223409 (1993-06-01), Ladner
patent: 5403484 (1995-04-01), Ladner
patent: 5759817 (1998-06-01), Barbas
patent: WO 94/18219 (1994-08-01), None
patent: WO 94/18221 (1994-08-01), None
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Barbas Carlos F.
Burton Dennis R.
Lerner Richard A.
Fitting Thomas
McCarthy Michael J.
Schwadron Ronald D.
The Scripps Research Institute
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