Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1996-07-03
1999-01-12
Davenport, Avis M.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530300, 514 12, A61K 3800, C07K 500, C07K 700
Patent
active
058591869
ABSTRACT:
A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.
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Gohil Kishor Chandra
Justice Alan
Miljanich George P.
Singh Tejinder
Valentino Karen L.
Davenport Avis M.
Dehlinger Peter J.
Neurex Corporation
Stratford Carol A.
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