Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1998-04-24
2000-12-19
Weber, Jon P.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435188, 424 9464, C12N 996, C12N 948, A61K 3848
Patent
active
061626295
ABSTRACT:
The present invention is broadly directed to a method for reducing autodegradation of activated protein C during processing and purification. The present invention provides aqueous activated protein C solutions and an improved method of processing of such solutions, comprising conducting such processing at an ionic strength of greater than 150 mM and at a pH of about 5.5 to less than 6.3.
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Baker Jeffrey Clayton
Carlson Andrew David
Huang Lihua
Sheliga Theodore Arsay
Barrett Brian P.
Caltrider Steve
Eli Lilly and Company
Norman Doug
Weber Jon P.
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