Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2007-08-07
2007-08-07
Lankford, Jr., Leon B (Department: 1651)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S325000, C204S454000, C204S450000, C204S451000, C977S904000, C977S920000
Reexamination Certificate
active
10374759
ABSTRACT:
Methods for reducing surface adsorption of biological materials to the walls of microfluidic conduits in microscale devices are provided. In an example of the methods, one or more colloidal-size particles, such as colloidal silica particles, are flowed in a fluid within the microfluidic conduit in the presence of one or more adherent biological materials (such as one or more proteins, cells, carbohydrates, nucleic acids, lipids and the like) to adsorb to the materials and prevent them from binding to the capillary walls of the microfluidic conduit. Other adsorption inhibition agents such as detergents and nonaqueous solvents can be used alone or in combination with colloidal particles to reduce surface adsorption in microfluidic conduits.
REFERENCES:
patent: 4229536 (1980-10-01), DeFilippi
patent: 5296114 (1994-03-01), Manz
patent: 5567292 (1996-10-01), Madabhushi et al.
patent: 5639505 (1997-06-01), Kossovsky et al.
patent: 5693784 (1997-12-01), Ekenberg
patent: 5699157 (1997-12-01), Parce
patent: 5779868 (1998-07-01), Parce et al.
patent: 5800690 (1998-09-01), Chow et al.
patent: 5842787 (1998-12-01), Kopf-Sill et al.
patent: 5885470 (1999-03-01), Parce et al.
patent: 6319095 (2001-11-01), Merchant et al.
patent: 6458259 (2002-10-01), Parce et al.
patent: 6787016 (2004-09-01), Tan et al.
patent: 376611 (1990-07-01), None
patent: WO-9604547 (1996-02-01), None
patent: WO-9800231 (1998-01-01), None
patent: WO-9800705 (1998-01-01), None
patent: WO-9800707 (1998-01-01), None
patent: WO-9802728 (1998-01-01), None
patent: WO-9805424 (1998-02-01), None
patent: WO-9822811 (1998-05-01), None
patent: WO-9845481 (1998-10-01), None
patent: WO-9845929 (1998-10-01), None
patent: WO-9846438 (1998-10-01), None
patent: WO-9849548 (1998-11-01), None
Bousse, L.J. et al. (1998) “Parallelism in integrated fluidic circuits,” SPIE (1998) 3259:179-186.
Bruin, G.J.M. et al., “Capillary Zone Electrophoretic Separations of Proteins in Polyethylene Glycol-Modified Capillaries” Journal of Chromatogr., 471 (1989) 429-436.
Effenhauser, C.S. et al. “Glass Chips for High-Speed Capillary Electrophoresis Separations with Submicrometer Plate Heights” Anal. Chem. (1993) 65:2637-2642.
Effenhauser, C.S. et al. “High-Speed Separation of Antisense Oligonucleotides on a Micromachined Capillary Electrophoresis Device.” Anal. Chem. (1994) 66:2949-2953.
Erim, F.B. et al., “Performance of a physically adsorbed high-molecular-mass polyethyleneimine layer as coating for the separation of basic proteins and peptides by capillary electrophoresis” Journal of Chromatogr. (1995) 708:356-361.
Fan, Z.H. et al. Micromachining of Capillary Electrophoresis Injectors and Separators on Glass Chips and Evaluation of Flow at Capillary Intersections. Anal. Chem. (1994) 66:177-184.
Harrison, D.J. et al. “Capillary Electrophoresis and Sample Injection Systems Integrated on a Planar Glass Chip.” Anal. Chem. (1992) 64:1926-1932.
Harrison, D.J. et al. “Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip.” Science (1993) 261: 895-897.
Harrison, D.J. et al. “Towards Miniaturized Electrophoresis and Chemical System Analysis Systems on Silicon: An Alternative to Chemical Sensors.” Sensors and Actuators (1993) 10:107-116.
Hjerten, S. “High-Performance Electrophoresis: Elimination of Electroendosmosis and Solute Adsorption” J. Chromatogr., (1985) 347: 191-198.
Huang, M. et al., “Evaluation of Surface-bonded Polyethylene Glycol and Polyethylene Imine in Capillary Electrophoresis” J. Microcol. Sep. (1992) 4:135-143.
Jacobson, S.C. et al. “Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices” Anal. Chem. (1994) 66:1107-1113.
Jacobson, S.C. et al. “High Speed Separations on a Microchip.” Anal. Chem. (1994) 66:1114-1118.
Jacobson, S.C. et al. “Open Channel Electrochromatography on a Microchip” Anal. Chem. (1994) 66:2369-2373.
Jacobson, S.C. et al. “Precolumn Reactions with Electrophoretic Analysis Integrated on Microchip” Anal. Chem. (1994) 66:4127-4132.
Jacobson, S.C. et al. “Microchip electrophoresis with sample stacking” Electrophoresis (1995) 16:481-486.
Jacobson, S.C. et al. “Fused Quartz Substrates for Microchip Electrophoresis” Anal. Chem. (1995) 67: 2059-2063.
Jorgenson, J.W. “Zone Electrophoresis in Open-Tubular Capillaries” Trends Anal. Chem. (1984) 3:51-54.
Kopf-Sill, A.R. et al. “Complexity and performance of on-chip biochemical assays,” SPIE (1997) 2978:172-179 Feb. 10-11.
McCormick, “Capillary Zone Electrophoretic Separation of Peptides and Proteins Using Low pH Buffers in Modified Silica Capillaries” Anal. Chem., 60, 2322-2328 (1998).
Ramsey, J.M. et al. “Microfabricated chemical measurement systems” Nature Med. (1995) 1(10):1093-1096.
Seiler, K. et al. “Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip” Mitt Gebiete Lebensm. Hyg. (1994) 85:59-68.
Seiler, K. et al. “Electroosmotic pumping and valveless control of fluid flow within a manifold of capillaries on a glass chip” Anal. Chem. (1994) 66:3485-3491.
Towns, J.K. et al. “Synthesis and evaluation of epoxy polymer coatings for the analysis of proteins by capillary zone electrophoresis” Journal of Chromatogr. (1992) 599, 227-237.
Hafeman Dean G.
Zhou Aileen
Caliper Life Sciences, Inc.
Lankford, Jr. Leon B
McKenna Donald R.
Petersen Ann C.
LandOfFree
Methods for prevention of surface adsorption of biological... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for prevention of surface adsorption of biological..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for prevention of surface adsorption of biological... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3896487