Methods for prevention of post-inflammatory hyperpigmentation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Sulfur – selenium or tellurium compound

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514730, 514947, 424 59, 424 60, A61K 31045, A61K 3110, A61K 740

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active

048351911

ABSTRACT:
Compositions of hydroquinone and an aliphatic sulfoxide of the formula ##STR1## wherein R.sub.1 and R.sub.2 are alkyl, substituted alkyl, alkenyl, or hetero groups, along with appropriate pharmaceutical diluents, excipients, and/or adjuvants are disclosed. The preferred aliphatic sulfoxide is dimethyl sulfoxide, and the sulfoxide content can range between about 1 and 99 weight percent, preferably between about 25 and 90 weight percent. The hydroquinone content ranges between about 1 and 10 weight percent, preferably between about 1.5 and 5 weight percent.
Also disclosed are various methods for preventing, eliminating, or substantially reducing post-inflammatory hyperpigmentation by applying these compositions to hyperpigmented tissue of hyman or animal subjects as often as necessry to remedy or alleviate the hyperpigmentation.

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Bleenan "Skin Bleaching Preparations" J. Soc. Cosm. Chem. 28 407-412 (1977) pp. 407-412.
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The Merck Index 9th ed. Dimethyl Sulfoxide (p. 433) and Hydroquinine (p. 635).

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