Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Milk or colostrum
Patent
1996-08-28
1999-09-14
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Milk or colostrum
514 12, 514 21, 530359, 530360, 530362, 530363, 530365, 530370, A61K 3520
Patent
active
059520094
ABSTRACT:
A method of preventing the transmission of or treating herpesvirus, such as herpes simplex virus infection, or Chlamydia trachomatis comprising administering to a patient a composition which comprises: (i) a protein or peptide containing lysines and an N-terminal amino group, wherein at least one of the lysines or the N-terminal amino group of the protein or peptide, such as casein, .beta.-lactoglobulin, powdered milk or whey, is modified by contact with an aromatic acid anhydride compound, such as trimellitic anhydride, trimellitic anhydride chloride or 3-hydroxyphthalic anhydride and/or (ii) a protein or peptide containing arginines, which is modified by an arginine modifying agent containing at least one carboxyl group, such as p-carboxyphenylglyoxal.
REFERENCES:
patent: 4585656 (1986-04-01), Rosenthal et al.
patent: 5010167 (1991-04-01), Ron et al.
patent: 5164486 (1992-11-01), Tsunoo et al.
patent: 5256412 (1993-10-01), Tsunoo et al.
patent: 5290571 (1994-03-01), Bounous et al.
patent: 5456924 (1995-10-01), Bounous
Chemical Abstracts, vol. 105, No. 17, Oct. 27, 1986, Columbus, OH, abstract No. 148687, V. Siksnis et al., "Stabilization of Enzymes by their Chemical Modification with Cyclic Aromatic Acid Anhydrides", Dokl. Akad. Nauk. SSSR, vol. 288, No. 6, 1986 (1508-1512).
Chemical Abstracts, vol. 103, No. 23, Dec. 9, 1985, Columbus, OH, abstract No. 192648, R.J.M Parker & R.S. Hodges, "Photoaffinity Probes Provide a General Method to Prepare Peptide Conjugates from Native Protein Fragments", J. Prot. Chem., vol. 3, No. 5-6, 1984 (479-489).
Ostresh, J.M., Husar, G.M., Blondelle, S.E., Dorner, B., Weber, P.A., and Houghten, R.A., "Libraries from libraries: Chemical Transformation of Combinatorial Libraries to Extend the Range and Repertoire of Chemical Diversity", Proc. Natl. Acad. Sci. USA, 91, 11138-11142 (1994).
Abraham, R., Singh, N., Mukhopadhyay, A., Basu, S.K., Bal, V., and Rath, S., "Modulation of Immunogenicity and Antigenicity of Proteins by Maleylation to Target Scavenger Receptors on Macrophages", J. Immunol., 154, 1-8 (1994).
Lo, T.W.C., Westwood, M.E., McLellan, A.C., Selwood, T. and Thornalley, P.J., "Binding and Modification of Proteins by Methylglyoxal Under Physiological Conditions. A Kinetic and Mechanistic Study with N.alpha.-Acetylarginine, N.alpha.-Acetylcysteine, and N.alpha.-Acetyllysine, and Bovine Serum Albumin", J. Biol. Chem., 269, 32299-32305 (1994).
Westwood, M.E., McLellan, A.C., and Thornalley, P.J., "Receptor-mediated Endocytic Uptake of Methylglyoxal-modified Serum Albumin. Competition with Advanced Glycation End Product-modified Serum Albumin at the Advanced Glycation End Product Receptor", J. Biol. Chem., 269, 32293-32298 (1994).
McKenzie, H.A., "Whole casein: Isolation, Properties, and Zone Electrophoresis", In: Milk Proteins Chemistry and Molecular Biology, vol. II., H.A. McKenzie (ed.), pp. 87-116. Academic Press, New York (1971).
Jansen, R.W., Molema, G., Pauwels, R., Schols, D., DeClercq, E. and Meijer, D.K.F., "Potent In Vitro Anti-Human Immunodeficiency Virus-1 Activity of Modified Human Serum Albumins", Molecular Pharmacology, 39, 818-823 (1991).
Takami, M., Sone, T., Mizumoto, K., Kino, K., and Tsunoo, H., "Maleylated Human Serum Albumin Inhibits HIV-1 infection in Vitro", Biochem. Biophys. Acta., 1180, 180-186 (1992).
Muckerheide, A., Apple, R.J., Pesce, A.J. and Michael, J.G., "Cationization of Protein Antigens", I. Alteration of Immunogenic Properties, The Journal of Immunology, 138, 833-837 (1987).
Suzuki, T., Burlingame, R.W., Cavalot, F., Andres, G., Kashiwazaki, S. and Tan, E.M., "Antibodies in Rabbits Immunized with Cationized IgG React with Histones H3 and H4", Arthritis and Rheumatism, 35, 1218-1226 (1992).
Virology, Fields, B.N., ed., Second Edition, Chapter 64, "Herpesviridae: A Brief Introduction", Bernard Roizman, 1787-1793 (1990).
Lundblad, R.L., Chemical Reagents for Protein Modification, 2nd Edition, CRC Press, Chapter 10, "The Modification of Lysine", 129-171 (1991).
Swart, P.J. and Meijer, D.K.F., "Negatively-charged Albumins: A Novel Class of Polyanionic Proteins with a Potent Anti-HIV Activity", International Antiviral News, 2, 69-71 (1994).
Kuipers, M.E., Huisman, J.G., Swart, P.J., de Bethune, M.-P., Pauwels, R., Schuitemaker, H., De Clercq, E. and Meijer, D.K.F., "Mechanism of Anti-HIV Activity of Negatively Charged Albumins: Biomolecular Interaction with the HIV-1 Envelope Protein gp120", Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 11, 419-429 (1996).
Harmsen, M.C., Swart, P.J., de Bethune, M.-P., Pauwels, R., De Clercq, E., The, T.H. and Meijer, D.K.F., "Antiviral Effects of Plasma and Milk Proteins: Lactoferrin Shows Potent Activity against Both Human Immunodeficiency Virus and Human Cytomegalovirus Replication In Vitro", JID, 172, 380-388 (1955).
Gordon, L.M., Waring, A.J., Curtain, C.C., Kirkpatrick, A., Leung, C., Faull, K. and Mobley, P.W., "Antivirals That Target the Amino-Terminal Domain of HIV Type 1 Glycoprotein 41", AIDS Research and Human Retroviruses, 11, 677-686 (1995).
Neyts, "Effect of Polyanionic on Vaginal Herpes" J. of Acquired Immune Deffic. Syndrome & Human Retrovirology v. 10, pp. 10-12, (1995).
Zaretsky, "Sulfated Polyanions Block Chlamydia trachomatis" Infection & Immunity, (Sep. 1995) v. 63, No. 9, pp. 3520-3526.
Zaretsky, "Sulfated Polyanions Block Chlampdia" (Abstract) Biosis #95: 439564 (1995).
Barnchez, "Anti-HIV Activity of Whey Portein" Teum Intl. Conference on AIDs (1994).
Tena-Quintero, "Virucidal Enzymic Milk Hydroxyzates" (1989) Caplus #1991: 49564.
Neyts, "Effects Polyanionic Compounds on Herpes & HIV" (1995) Caplus #1995: 942514.
Debnath Asim Kumar
Jiang Shibo
Neurath Alexander Robert
Delaney Patrick R.
New York Blood Center
Robinson Douglas W.
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