Methods for preventing progressive tissue necrosis, reperfusion

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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A61K 3156

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active

056864388

ABSTRACT:
The present invention is directed to a method for preventing or reducing ischemia following injury, such as reperfusion injury following ischemia, cellular damage associated with ischemic episodes, such as infarctions or traumatic injuries, and thus to prevent or reduce the consequent progressive necrosis of tissue associated with such ischemia. This effect is achieved by administering DHEA, DHEA derivatives or DHEA congeners to a patient as soon as possible after the injury. The present invention is further directed to methods for preventing or reducing bacterial translocation or adult respiratory distress syndrome in a patient. Similarly, bacterial translocation and adult respiratory distress syndrome are prevented or reduced by administering DHEA, DHEA derivatives or DHEA congeners to a patient.

REFERENCES:
patent: 4898694 (1990-02-01), Schwartz et al.
patent: 5001119 (1991-03-01), Schwartz et al.
patent: 5110810 (1992-05-01), Eich et al.
patent: 5162198 (1992-11-01), Eich et al.
patent: 5175154 (1992-12-01), Schwartz et al.
Simon, R.H. et al. (1992). "Adult Respiratory Distress Syndrome," Information: Basic Principles and Clinical Correlates, 2nd Ed., J. Gallin et al., Eds., Raven Press (N.Y.), pp. 999-1016.
Meikle, A.W. et al. (1991). "Adrenal Androgen Secretion and Biologic Effects," Endo- crinol. Metab. Clin. N. Am. 29:2, pp. 381-400.
Vedder, N.B. et al. (1990). "Inhibition of Leukocyte Adherence by Anti-CD18 Monoclonal Antibody Attenuates Reperfusion Injury in the Rabbit Ear," Proc. Nat. Acad. Sci. USA 87:2643-2646.
Dolocek, R. (1989). "Endocrine Changes after Burn Trauma-A Review," Keio J. Med. 38(3):262-276.
Gordon, G. et al. (1987). "Modulation of Growth, Differentiation and Carcinogenesis by Dehydroepiandrosterone," Adv. Enz. Regul. 26:355-378.
Erlich, H.P. (1984). "Anti-inflammatory Drugs in the Vascular Response to Burn Injury," J. Trauma 24(4):311-317.
Robson, M.C. (1990). "Increasing Dermal Perfusion after Burning by Decreasing Thromboxane Production," J. Trauma 20(9):722-725.
Robson, M.C. (1978). "The Effect of Prostaglandins on the Dermal Microcirculation After Burning, and the Inhibition of the Effect by Specific Pharmcological Agents," Annual Meeting of the American Society of Plastic and Reconstructive Surgeons, Hollywood, Florida, Nov. 8, 1978.

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